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Desensitization to ANG II in guinea pig ileum depends on membrane repolarization: role of maxi-K+ channel
(Amer Physiological Soc, 1999-10-01)
Desensitization of ANG II tonic contractile response of the guinea pig ileum is related to membrane repolarization determined by Ca2+-activated K+ (maxi-K+) channel opening. ANG II-stimulated depolarized myocytes presented ...
Different mechanism of LPS-induced vasodilation in resistance and conductance arteries from SHR and normotensive rats
(Nature Publishing Group, 2002-09-01)
1 the direct and endothelium-dependent effects of lipopolysaccharide (LPS) were investigated on resistance and conductance arteries from normotensive Wistar (NWR) and spontaneously hypertensive (SHR) rats.2 in both NWR and ...
Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet
(2006-07-12)
Type II Bartter's syndrome is a hereditary hypokalemic renal salt-wasting disorder caused by mutations in the ROMK channel (Kir1.1; Kcnj1), mediating potassium recycling in the thick ascending limb of Henle's loop (TAL) ...
Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet
(2006-07-12)
Type II Bartter's syndrome is a hereditary hypokalemic renal salt-wasting disorder caused by mutations in the ROMK channel (Kir1.1; Kcnj1), mediating potassium recycling in the thick ascending limb of Henle's loop (TAL) ...
Endothelium-dependent desensitization to angiotensin II in rabbit aorta: the mechanisms involved
(Canadian Science Publishing, 2001-12)
The aim of this study was to characterize the role of the endothelium in angiotensin II-desensitization and its mechanisms of action. Rabbit aortic rings were exposed to increasing doses of angiotensin II (Ang II, 10–9 to ...
Characterization of alpha(2)-adrenoceptors in smooth muscles of the spontaneously hypertensive rat aorta
(Elsevier B.V., 2003-02-01)
Previous works have shown that the alpha(2)-adrenoceptor agonist UK 14,304 induced the relaxation and hyperpolarization of the rat aorta, mediated by alpha(2)-adrenoceptors present in the smooth muscles, through ...
Signaling path of the action of AVP on distal K+ secretion
(Blackwell Publishing, 2004-08-01)
Background. Previous studies from our laboratory have shown that luminal perfusion with arginine vasopressin (AVP) stimulates distal tubule secretory potassium flux (J(K)) via V1 receptors (Am J Physiol 278: F809- F816, ...
Signaling path of the action of AVP on distal K+ secretion
(Blackwell Publishing, 2004-08-01)
Background. Previous studies from our laboratory have shown that luminal perfusion with arginine vasopressin (AVP) stimulates distal tubule secretory potassium flux (J(K)) via V1 receptors (Am J Physiol 278: F809- F816, ...
Determination of the Stoichiometry between α- and γ1 Subunits of the BK Channel Using LRET
(Biophysical Society, 2018)
© 2018 Biophysical Society Two families of accessory proteins, β and γ modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the γ1 subunit promotes a large shift of the BK conductance-voltage ...