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Influence of hairy root ecotypes on production of tropane alkaloids in Brugmansia candida
(Springer, 2013-09)
Hyoscyamine and scopolamine are tropane alkaloids widely applied in medicine. Differences in alkaloids production and growth kinetics were observed for Argentinean and Colombian ecotypes of Brugmansia candida hairy roots. ...
Production of tropane alkaloids by biotransformation using recombinant Escherichia coli whole cells
(Elsevier Science Sa, 2017-09)
Tropane alkaloids, such as hyoscyamine, 6β-hydroxyhyoscyamine and scopolamine, are secondary metabolites that were traditionally applied in medicine due to their anticholinergic activity. Hyoscyamine is converted into ...
Analytical considerations for the successful evaluation of hyoscyamine biotransformation into 6b-hydroxyhyoscyamine and scopolamine
(Colegio de Farmacéuticos de la Provincia de Buenos Aires, 2012-05)
Hyoscyamine, 6B-hydroxyhyoscyamine and scopolamine are anticholinergic agents that be-long to the tropane alkaloids, a pharmacological important group of secondary metabolites. Hyoscyamine and scopolamine were historically ...
Analysis and sequencing of h6hmRNA, last enzyme in the tropane alkaloids pathway from anthers and hairy root cultures of Brugmansia candida (Solanaceae)
(Pontificia Universidad Católica de Valparaíso, 2006)
Elicitation of in vitro cultivated roots of brugmansia candida (solanaceae) with larginine, precursor of tropane alkaloidsElicitación de raíces cultivadas in vitro de brugmansia candida (solanaceae) con L-arginina, precursor de alcaloides del tropano
(Pereira : Universidad Tecnológica de PereiraFacultad de Ciencias Básicas, 2011)
Mechanism of neuromuscular blockade induced by phenthonium, a quaternary derivative of (-)-hyoscyamine, in skeletal muscles
(Stockton Press, 1998-07-01)
1 the mechanisms underlying the postjunctional blockade induced by phenthonium [N-(4-phenyl) phenacyl 1-hyoscyamine] were investigated in mammalian and amphibian muscles. This muscarinic antagonist was previously shown to ...
Effect of jasmonic acid and aluminium on production of tropane alkaloids in hairy root cultures of Brugmansia candida
(Pontificia Universidad Católica de Valparaíso, 2000)
Determination of Atropine Enantiomers in Ophthalmic Solutions by Liquid Chromatography Using a Chiral AGP (R) Column
(AOAC INT, 2009)
Many therapeutic agents are commercialized under their racemic form. The enantiomers can show differences in the pharmacokinetic and pharmacodynamic profile. The use of a pure enantiomer in pharmaceutical formulations may ...
Occurrence of cadaverine in hairy roots of Brugmansia candida
(PERGAMON-ELSEVIER SCIENCE LTD, 2001-07)
The polyamine, cadaverine, was detected in transformed root cultures of Brugmansia candida (syn. Datuira candida), a Solanaceae which produces the tropane alkaloids scopolamine and hyoscyamine. To the best of our knowledge, ...