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Design of inhibitors for human tissue kallikrein using non-natural aromatic and basic amino acids
(Walter de Gruyter & Co, 2002-05-01)
We explored the unique substrate specificity of the primary S1 subsite of human urinary kallikrein (hK1), which accepts both Phe or Arg synthesizing and assaying peptides derived from PhenylacetylPheSer ArgEDDnp, a previously ...
The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins
(Bioorganic & Medicinal Chemistry Letters, 2018)
Protective actions of human tissue kallikrein gene in transgenic rat hearts
(Elsevier B.V., 2008-02-01)
In this study, we used an experimental model. of cardiac hypertrophy to explore the role of the kallikrein-kinin system (KKS) in cardiac protection in transgenic rats harboring the human tissue kallikrein gene, TGR(hKLK1). ...
Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia
(JOHN WILEY & SONS INC, 2010)
Overexpression of kallikrein 7, a proteolytic enzyme important for epithelial cell shedding, may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion. In this study, we have evaluated hK7 ...