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A pragmatic stepped-wedge cluster randomized trial to evaluate the effectiveness and cost-effectiveness of active case finding for household contacts within a routine tuberculosis program, San Juan de Lurigancho, Lima, Peru
(Elsevier, 2020)
Background: Active case finding (ACF) in household contacts of tuberculosis (TB) patients is now recommended for National TB Programs (NTP) in low- and middle-income countries. However, evidence supporting these recommendations ...
A household-level score to predict the risk of tuberculosis among contacts of patients with tuberculosis: a derivation and external validation prospective cohort study
(Elsevier, 2020)
Background: The epidemiological impact and cost-effectiveness of social protection and biomedical interventions for tuberculosis-affected households might be improved by risk stratification. We therefore derived and ...
Early detection of leprosy by examination of household contacts, determination of serum anti-PGL-1 antibodies and consanguinity
(Instituto Oswaldo Cruz, Ministério da Saúde, 2011)
A cross-sectional clinical trial in which the serum anti-phenolic glycolipid (anti-PGL-1) antibodies were analysed in household contacts (HHC) of patients with leprosy as an adjunct early leprosy diagnostic marker was ...
Transmission of Multidrug-Resistant and Drug-Susceptible Tuberculosis within Households: A Prospective Cohort Study
(Public Library of Science, 2015)
BACKGROUND: The "fitness" of an infectious pathogen is defined as the ability of the pathogen to survive, reproduce, be transmitted, and cause disease. The fitness of multidrug-resistant tuberculosis (MDRTB) relative to ...
Risk of tuberculosis among household contacts in Salvador, Bahia
(Brazilian Journal of Infectious Diseases, 2004)
Tuberculosis is one of the most important infectious diseases in the world. Only 68% of the estimated new tuberculosis (TB) cases in Brazil are diagnosed. Our aim was to determine the risk of infection among household ...
Efficacy and tolerability of ciprofloxacin prophylaxis in adult household contacts of patients with cholera
(Oxford University Press, 1995)
We conducted a randomized double-blinded study in Lima, Peru, to assess the tolerability and efficacy of a single 250-mg dose of ciprofloxacin in preventing diarrhea and Vibrio cholerae O1 infection among household contacts ...
Fitness of drug resistant Mycobacterium tuberculosis and the impact on the transmission among household contacts
(Churchill Livingstone, 2014)