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High-dose methotrexate therapy of childhood acute lymphoblastic leukemia: Lack of relation between serum methotrexate concentration and creatinine clearance
(2004)
Background. The objectives of this study were: (1) to analyze the relation of serum methotrexate (MTX) concentration with creatinine clearance, (2) to compare the leucovorin rescue dose administered to the patients based ...
Acute high-risk pulmonary embolism requiring thrombolytic therapy in a COVID-19 pneumonia patient despite intermediate dosing deep vein thromboprophylaxis
Cytokine storm induced by the coronavirus 19 (COVID-19) profoundly activates the coagulation
cascade causing venous thromboembolism (VTE). Initial studies from Wuhan, China showed
increased incidence of VTE in patients ...
Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism
(WILEY-BLACKWELL, 2012)
Background Mercaptopurine and azathioprine (AZA) are efficacious in treating IBD. 6-tioguanine (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with ...
High-dose cyclophosphamide followed by autologous peripheral blood progenitor cell transplantation improves the salvage treatment for persistent or sensitive relapsed malignant lymphoma
(Associação Brasileira de Divulgação Científica, 2002)
High-dose radioiodine outpatient therapyRadioiodoterapia ambulatorial de alta dose
(Sociedade Brasileira de Endocrinologia e Metabologia, 2009)
Induction pegylated interferon Alfa-2a and high dose ribavirin do not increase SVR in heavy patients with HCV genotype 1 and high viral loads
(2010-12-01)
Background & Aims Patients infected with hepatitis C virus (HCV) genotype 1, body weight <85 kg, and high baseline viral load respond poorly to standard doses of pegylated interferon (peginterferon) and ribavirin. We ...