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Altered resting-state functional connectivity in hiPSCs-derived neuronal networks from schizophrenia patients
(Frontiers Media, 2022)
Schizophrenia (SZ) is a severe mental disorder that arises from abnormal neurodevelopment, caused by genetic and environmental factors. SZ often involves distortions in reality perception and it is widely associated with ...
The Histone Demethylase JMJD2A Modulates the Induction of Hypertrophy Markers in iPSC-Derived Cardiomyocytes
(Frontiers in Genetics, 2018-02-09)
The development of cardiovascular pathologies is partly attributed to epigenetic causes, including histone methylation, which appears to be an important marker in hearts that develop cardiac hypertrophy. Previous studies ...
Generation of primordial germ cell-like cells from iPSCs derived from turner syndrome patients
(2021-11-01)
Turner syndrome (TS) is a genetic disorder in females with X Chromosome monosomy associated with highly variable clinical features, including premature primary gonadal failure leading to ovarian dysfunction and infertility. ...
Regulation of cyclin E1 expression in human pluripotent stem cells and derived neural progeny
(Landes Bioscience, 2018-07)
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells (hESCs and hiPSCs) show unique cell cycle characteristics, such as a short doubling time due to an abbreviated G1 phase. Whether ...
Generation and genetic repair of two human induced pluripotent cell lines from patients with Epidermolysis Bullosa simplex and dilated cardiomyopathy associated with a heterozygous mutation in the translation initiation codon of KLHL24
(2021)
Fibroblasts from two patients carrying a heterozygous mutation in the translation initiation codon (c.2 T > G) of the kelch-like protein 24 (KLHL24) gene were used to
generate human induced pluripotent stem cells (hiPSCs), ...
Desenvolvimento e caracterização de córneas humanas descelularizadas e recelularização com células-tronco visando regeneração do epitélio corneano anterior
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Biologia CelularUFMG, 2017-07-25)
Numerous diseases can affect corneal structure, leading to visual impairment and even
blindness. Currently, the only treatment for most corneal illnesses is transplantation of corneal
allografts. However, graft rejection ...
Avaliação do tratamento com VU0409551 em astrócitos derivados de hiPSCs estimulados com citocinas pró-inflamatórias associadas à Esclerose Múltipla
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIACurso de Especialização em Bioquímica e ImunologiaUFMG, 2022-07-21)
Multiple sclerosis (MS) is a neuroinflammatory, autoimmune, chronic and disabling
disease that affects the central nervous system due to an autoimmune response
against myelin proteins, along with the formation of ...
Schizophrenic patients hiPSC-derived astrocytes impair synaptic material engulfment by induced microglial-like cells (iMGs)
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2022-08-23)
A esquizofrenia (SCZ) é uma desordem psiquiátrica, cujas causas estão associadas à interação entre fatores genéticos e ambientais. Indivíduos com esquizofrenia apresentam sintomas classificados como positivos (delírios, ...
Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199
(Public Library of Science, 2016-03)
Human embryonic stem cells (hESCs) are hypersensitive to genotoxic stress and display lower survival ability relative to their differentiated progeny. Herein, we attempted to investigate the source of this difference by ...