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Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells
(Ulrich Brandt, 2020-08-29)
The signaling events triggered by soluble mediators released from both transformed and stromal cells shape the
phenotype of tumoral cells and have significant implications in cancer development and progression. In this
study ...
Análise proteômica da sinalização heterotípica em cultura celular de melanoma
(Universidade Federal de São Paulo (UNIFESP), 2021)
The signaling events triggered by soluble mediators released from both transformed and stromal cells shape the phenotype of tumoral cells and have significant implications in cancer development and progression. In this ...
Secretome profiling of heterotypic spheroids suggests a role of fibroblasts in HIF-1 pathway modulation and colorectal cancer photodynamic resistance
(Springer Heidelberg, 2019-04)
Previous analyses of the tumor microenvironment (TME) have resulted in a concept that tumor progression may depend on interactions between cancer cells and its surrounding stroma. An important aspect of these interactions ...
A heterotypic tridimensional model to study the interaction of macrophages and glioblastoma in vitro
(Molecular Diversity Preservation International, 2021-05)
Background: Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor, and macrophages account for 30–40% of its composition. Most of these macrophages derive from bone marrow monocytes playing ...
Modulation of metabolic communication through gap junction channels by transjunctional voltage; synergistic and antagonistic effects of gating and ionophoresis
(2012)
Gap junction (GJ) channels assembled from connexin (Cx) proteins provide a structural basis for direct electrical and metabolic cell-cell communication. Here, we focus on gating and permeability properties of Cx43/Cx45 ...
Rotavirus vaccines for the developing world
(Lippincott Williams, 2009)
The authors discuss the most relevant information in the field of rotavirus vaccines
published from October 2007 to June 2009; new information on the virus, host
response and disease burden that relate to our understanding ...
Reciprocal changes in gene expression profiles of cocultured breast epithelial cells and primary fibroblasts
(WILEY-LISS, 2009)
The importance of epithelial-stroma interaction in normal breast development and tumor progression has been recognized. To identify genes that were regulated by these reciprocal interactions, we cocultured a nonmalignant ...
Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice
(Amer Soc HematologyWashingtonEUA, 2012)