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BCG-induced cross-protection and development of trained immunity: implication for vaccine design
(2019)
The Bacillus Calmette-Guerin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with ...
Evaluation of humoral and cellular immune response after heterologous prime-boost immunization against SARS-CoV-2
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2021)
Leukotrienes are not essential for the efficacy of a heterologous vaccine against Mycobacterium tuberculosis infection
(Associação Brasileira de Divulgação Científica (ABRADIC), 2010-07-01)
Leukotrienes are reported to be potent proinflammatory mediators that play a role in the development of several inflammatory diseases such as asthma, rheumatoid arthritis and periodontal disease. Leukotrienes have also ...
The localization of a heterologous displayed antigen in the baculovirus-budded virion determines the type and strength of induced adaptive immune response
(2017-05)
In the search of strategies of presentation of heterologous antigens to elicit humoral or cellular immune responses that modulate and properly potentiate each type of response, researchers have been studying baculovirus ...
Memory immune responses and protection of chickens against a nephropathogenic infectious bronchitis virus strain by combining live heterologous and inactivated homologous vaccines
(2019-01-01)
In this study, we evaluated antibody and cell-mediated immune (CMI) responses in the mucosal and systemic compartments and protection against challenge with a nephropathogenic Brazilian (BR-I) strain of infectious bronchitis ...
Evaluation of different heterologous prime–boost immunization strategies against Babesia bovis using viral vectored and protein-adjuvant vaccines based on a chimeric multi-antigen
(Elsevier, 2016-07)
Protection against the intraerythrocytic bovine parasite Babesia bovis requires both humoral and cellular immune responses. Therefore, tailored combinations of immunogens targeted at both arms of the immune system are ...
Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA
(American Society for Microbiology, 2023)
Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4(+)/CD4(+) Foxp3(+) cells
(WILEY-BLACKWELLHOBOKEN, 2012)
CD4(+) Foxp3(+) regulatory T cells inhibit the production of interferon-?, which is the major mediator of protection against Mycobacterium tuberculosis infection. In this study, we evaluated whether the protection conferred ...
BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design
(Facultad de Medicina y Ciencia, 2019)
The Bacillus Calmette-Guerin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease. Vaccination with ...