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Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003)
We examined in vivo a role for sterol carrier protein-2 (SCP-2) in the regulation of lipid secretion across the hepatic sinusoidal and canalicular membranes. Recombinant adenovirus Ad.rSCP2 was used to overexpress SCP-2 ...
Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice
(WILEY, 2011)
Background & aims: Bile acid (BA) pool size remains unchanged after cholecystectomy (XGB) but it circulates faster, exposing the enterohepatic system to an increased flux of BA. Triglyceride (TG) and BA metabolisms are ...
Characterization of lipid metabolism genes and the influence of fatty acid supplementation in the hepatic lipid metabolism of dusky grouper (Epinephelus marginatus)
(Elsevier B.V., 2018-05-01)
Dusky grouper is an important commercial fish species in many countries, but some factors such as overfishing has significantly reduced their natural stocks. Aquaculture emerges as a unique way to conserve this species, ...
Moderate physical activity from childhood contributes to metabolic health and reduces hepatic fat accumulation in adult rats
(2013-03-08)
Background: Obesity, oxidative stress and inflammation, by triggering insulin resistance, may contribute to the accumulation of hepatic fat, and this accumulation by lipotoxicity can lead the organ to fail. Because obesity ...
Moderate physical activity from childhood contributes to metabolic health and reduces hepatic fat accumulation in adult rats
(2013-03-08)
Background: Obesity, oxidative stress and inflammation, by triggering insulin resistance, may contribute to the accumulation of hepatic fat, and this accumulation by lipotoxicity can lead the organ to fail. Because obesity ...
Central cellular signaling pathways involved with the regulation of lipid metabolism in the liver: A review
(2020-01-01)
The liver is primarily responsible for energy homeostasis and the regulation of lipid, carbohydrate and protein metabolism. Lipid metabolism consists of distributing lipids to peripheral tissues or ensuring their return ...
Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease
(JOHN WILEY & SONS INC, 2007)
A strong interrelationship exists between the regulation of bile acid (BA) metabolism and hepatic very low density lipoprotein (VLDL) production. We have recently shown that BA synthesis is increased in gallstone disease. ...
Improvement In The Expression Of Hepatic Genes Involved In Fatty Acid Metabolism In Obese Rats Supplemented With Taurine
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2015)
Inactivation of hepatic microsomal triglyceride transfer protein protects mice from diet-induced gallstones
(W B SAUNDERS CO-ELSEVIER INC, 2006)
Background & Aims: Microsomal triglyceride transfer protein (MTTP) is critical for the production of very-low-density lipoproteins (VLDL). The current studies were undertaken to examine the in vivo role of MTTP in hepatic ...