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Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione
(2012)
Trypanosoma cruzi glutamate cysteine ligase (TcGCL) is considered a potential drug target to develop novel antichagasic drugs. We have used a variety of computational methods to investigate the interactions between TcGCL ...
Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi
(Bentham Science Publishers B.V., 2014)
In trypanosomatids, redox homeostasis is centered on trypanothione (N 1,N8-bis(glutathionyl)spermidine, T(SH)2), a low molecular weight thiol that is distinctive for this taxonomic family and not present in the mammalian ...
Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease
(WILEY-BLACKWELL PUBLISHING, INC, 2010)
Background and Aims: Although the metabolic risk factors for non-alcoholic fatty liver disease (NAFLD) progression have been recognized, the role of genetic susceptibility remains a field to be explored. The aim of this ...
Upregulation of γ-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neuronal SH-SY5Y cells
(2007)
Reactive iron is an important prooxidant factor, whereas GSH is a crucial component of a long-term adaptive system that allows cells to function during extended periods of high oxidative stress. In this work, the adaptive ...
Upregulation of gamma-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neuronal SH-SY5Y cells
(2007)
Reactive iron is an important prooxidant factor, whereas GSH is a crucial component of a long-term adaptive system that allows cells to function during extended periods of high oxidative stress. In this work, the adaptive ...
FSH and bFGF stimulate the production of glutathione in cultured rat sertoli cells
(Wiley Blackwell Publishing, Inc, 2009-06)
Migration of developing germ cells from the basal to the adluminal compartment of the seminiferous epithelium requires extensive tissue restructuring, resulting in the production of reactive oxygen species. Sertoli cells ...
Bisphenol A effect on glutathione synthesis and recycling in testicular Sertoli cells
(Editrice Kurtis S R L, 2010-10)
Abstract Background and objective: Controversial effects of bisphenol A (BPA) have been reported on testicular function. These differences might reflect dissimilar exposure conditions. Dose responses to toxicants may be ...
Glutathione and glutathione peroxidase expression in breast cancer: An immunohistochemical and molecular study
(2013-09-01)
The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a ...
Glutathione and glutathione peroxidase expression in breast cancer: An immunohistochemical and molecular study
(2013-09-01)
The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a ...