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LPS regulates the expression of glucocorticoid receptor alpha and beta isoforms and induces a selective glucocorticoid resistance in vitro
(Biomed Central Ltd., 2017)
Background: This study was aimed to evaluate the effect of LPS in glucocorticoid receptor (GR) isoforms expression on different cell lines and PBMC from healthy donors in vitro and glucocorticoid sensitivity of PBMC in ...
Seasonal Changes and Regulation of the Glucocorticoid Receptor in the Testis of the Toad Rhinella arenarum
(Wiley, 2012-11)
Several studies indicate that wild free‐living vertebrates seasonally regulate plasma glucocorticoids. However, not only glucocorticoids but also the amount of receptors is important in determining biological responses. ...
Effects of methotrexate on the expression of the translational isoforms of glucocorticoid receptors α and β: Correlation with methotrexate efficacy in rheumatoid arthritis patients
(2011)
Objectives: To test the effect of MTX on the expression of glucocorticoid receptor (GR) α and β isoforms AB, C and D in peripheral blood mononuclear cells (PBMCs) in culture, from newly diagnosed RA patients and to evaluate ...
NF-kappa b expression predicts clinical outcome for nasal polyposis
(INT RHINOLOGIC SOC, 2010)
Objective: To correlate clinical prognosis of patients with nasal polyps to the expression of p65, c-Fos, GR alpha and GR beta. Methods: A biopsy was obtained at the first evaluation of patients with nasal polyps, and at ...
Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus
(Elsevier, 2019-03)
Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine ...
Mecanismos moleculares involucrados en la modulación de la actividad del receptor de glucocorticoidesMolecular mechanism underlying glucocorticoid receptor´s activity modulation
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2010)
Therapeutic utility of glucocorticoids and antihistamines cotreatment. Rationale and perspectives
(Wiley, 2019-12)
Antihistamines and glucocorticoids (GCs) are often used together in the clinic, in several inflammatory-related situations. Even though there is no clear rationale for this drug association, the clinical practice is based ...
21-Hydroxy-6,19-epoxyprogesterone: A promising therapeutic agent and a molecular tool for deciphering glucocorticoid action
(Bentham Science Publishers, 2016-06)
Glucocorticoids are steroid hormones that exert most of their effects through their binding to the glucocorticoid receptor (GR), a ligand regulated transcription factor. Although glucocorticoids are widely used in the ...
Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome
(Cold Spring Harbor Laboratory Press, 2019-08)
Most transcription factors, including nuclear receptors, are widely modeled as binding regulatory elements as monomers, homodimers, or heterodimers. Recent findings in live cells show that the glucocorticoid receptor NR3C1 ...
Cytosolic glucocorticoid receptor in the testis of Bufo arenarum: Seasonal changes in its binding parameters
(Elsevier Inc, 2006-07)
Glucocorticoids (GC) are the hormonal mediators of stress. In mammals, high levels of GC have negative eVects on reproductive physiology. For instance, GC can inhibit testicular testosterone synthesis by acting via ...