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Protective effect of quercetin in gentamicin-induced oxidative stress in vitro and in vivo in blood cells: effect on gentamicin antimicrobial activity
(Elsevier Science, 2016-11)
We have evaluated the effect of gentamicin and gentamicin plus quercetin on ROS production, endogenous antioxidant defenses (SOD and CAT) and lipid peroxidation in vitro on human leukocytes and in vivo on whole rat blood. ...
Gentamicin attenuates gentamicin-induced ototoxicity - Self-protection
(TAYLOR & FRANCIS INC, 2008)
Aminoglycoside antibiotics cause considerable toxicity to the inner ear. A progressive hearing loss at high frequencies resulted from the loss of hair cells in the base of the cochlea and a constant preoccupation with ...
Histological effects of intratympanic gentamicin on the vestibular organ of guinea pigs
(CAMBRIDGE UNIV PRESS, 2011)
Background: Transtympanic administration of gentamicin may be suitable to achieve unilateral vestibular ablation, in order to control unilateral Meniere`s disease. In low doses, gentamicin appears to affect selectively the ...
Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib
(Oxford University Press, 2021)
OBJECTIVES: KPC-producing Klebsiella pneumoniae (KPC-Kp) isolates commonly co-harbour the aminoglycoside-modifying enzyme (AME) gene aac(6')-Ib, which encodes an AME that can confer resistance to some of the commercially ...
Effect of Withania somnifera on gentamicin induced renal lesions in rats
(Soc Brasileira Farmacognosia, 2019-03-01)
Gentamicin induced renal complications are well known in humans and animals. Medicinal properties of Withania somnifera (L.) Dunal, Solanaceae, are recognized to improve renal functions. However, the pharmacological function ...
BONE CEMENT AND GENTAMICIN IN THE TREATMENT OF BONE INFECTION. BACKGROUND AND IN VITRO STUDY
(ATHA COMUNICACAO & EDITORA, 2010)
Objective: To determine the elution characteristics of the antibiotic (gentamicin) mixed with bone cement. Methods: 480mg of gentamicin was added to 40g of bone cement. Ten specimens were immersed in buffered saline solution ...
Gentamicin-induced preconditioning of proximal tubular LLC-PK1 cells stimulates nitric oxide production but not the synthesis of heat shock protein
(Associação Brasileira de Divulgação Científica, 2009-07-01)
Nephrotoxicity is the main side effect of antibiotics such as gentamicin. Preconditioning has been reported to protect against injuries as ischemia/reperfusion. The objective of the present study was to determine the effect ...
Comparison of three experimental designs employed in gentamicin microbiological assay through agar diffusion
(Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2009)
Gentamicin is a broad-spectrum antibiotic complex produced by actinomycetes belonging to Micromonospora genus and classified among aminoglycoside antibiotics, used in the treatment of serious infections derived from ...