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Genetics of rheumatoid arthritis: A new boost is needed in Latin American populations
(Elsevier Editora Ltda, 2016)
Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment
(Elsevier, 2017)
The genetic basis of earlobe attachment has been a matter of debate since the early 20th century, such that geneticists argue both for and against polygenic inheritance. Recent genetic studies have identified a few loci ...
Pathogenesis of preeclampsia: The genetic component
(2012)
Preeclampsia (PE) is one of the main causes of maternal and fetal morbidity and mortality in the world, causing nearly 40% of births delivered before 35 weeks of gestation. PE begins with inadequate trophoblast invasion ...
A global reference for human genetic variation
(Springer Nature, 2015)
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report ...
Neurogenetics in Peru: clinical, scientific and ethical perspectives
(Springer, 2015)
Neurogenetics, the science that studies the genetic basis of the development and function of the nervous system, is a discipline of recent development in Peru, an emerging Latin American country. Herein, we review the ...
A genome-wide association study identifies multiple loci for variation in human ear morphology
(Springer Nature, 2015)
Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find genome-wide significant association at seven genomic regions affecting: lobe size and attachment, ...
Population, Epidemiological, and Functional Genetics of Gastric Cancer Candidate Genes in Peruvians with Predominant Amerindian Ancestry
(Springer, 2015)
Background. Gastric adenocarcinoma is associated with chronic infection by Helicobacter pylori and with the host inflammatory response triggered by it, with substantial inter-person variation in the immune response profile ...
Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci
(PLoS, 2023)
Human ear morphology, a complex anatomical structure represented by a multidimensional set of correlated and heritable phenotypes, has a poorly understood genetic architecture. In this study, we quantitatively assessed 136 ...
A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases
(American Association for the Advancement of Science, 2015)
Early regulators of disease may increase understanding of disease mechanisms and serve as markers for presymptomatic diagnosis and treatment. However, early regulators are difficult to identify because patients generally ...