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Synthesis and evaluation of diethylethylamine-chitosan for gene delivery: Composition effects on the in vitro transfection efficiency
(2013-02-08)
Chitosan has been indicated as a safe and promising polycation vector for gene delivery. However its low transfection efficiency has been a challenging obstacle for its application. To address this limitation, we synthesized ...
Efficient plasmid-mediated gene transfection of ovine bone marrow mesenchymal stromal cells
(Elsevier, 2013-01)
BACKGROUND AIMS: Given the close similarity between ovine and human cardiomyocytes, sheep models of myocardial infarction and heart failure are increasingly used in studies of stem cell-mediated heart regeneration. In these ...
Transfection of Gametes: A Method to Generate Transgenic Animals
(Sociedad Chilena de Anatomía, 2005)
Synthesis and evaluation of diethylethylamine-chitosan for gene delivery: Composition effects on the in vitro transfection efficiency
(2013-02-08)
Chitosan has been indicated as a safe and promising polycation vector for gene delivery. However its low transfection efficiency has been a challenging obstacle for its application. To address this limitation, we synthesized ...
Pharmaceutical emulsions: a new approach for gene therapy
(Informa Healthcare, 2010-06-01)
The concept of gene therapy involves the experimental transfer of a therapeutic gene into an individual's cells and tissues to replace an abnormal gene aiming to treat a disease, or to use the gene to treat a disease just ...
Aumento en la transfección genética de la línea celular PC-12 mediada por fármacos que aumentan la fusión celular e inhiben la función lisosomal
(25/02/2010)
ABSTRACT: Gene therapy can be defined as the introduction of genetic material into cells with the objective of altering the course of a disease. Efficient and safe genetic vehicles are one of the fundamental requirements ...
Transfection of exogenous DNA complexed to cationic dendrimer induces alterations of bovine sperm microRNAome
(2020-10-15)
MicroRNAs have been hypothesized to be involved in the regulation of male fertility potential. The primary aim of our study was to demonstrate the effects of transfection with dendrimer nanostructure on the parameters of ...