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Multiple gene knock-down by a single lentiviral vector expressing an array of short hairpin RNAs
(Pontificia Universidad Católica de Valparaíso, 2006)
CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos
(Elsevier, 2020)
The development of mRNA knockdown technologies for use in vertebrate organisms such as zebrafish has been limited. Kushawah et al. establish CRISPR-RfxCas13d as an efficient, specific, cost-effective, and straightforward ...
Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown
(National Academy of Sciences, 2022)
Analysis of the Gene Expression and RNAi-Mediated Knockdown of Chitin Synthase from Leaf-Cutting Ant Atta sexdens
(Soc Brasileira Quimica, 2020-10-01)
Chitin synthase (CHS) is the enzyme specifically associated with chitin synthesis, an important component of diverse organisms including insects. Two alternative spliced transcripts of the CHS gene (AsCHS-A1 and AsCHS-A2) ...
Hydrogen peroxide and Helicobacter pylori extract treatment combined with APE1 knockdown induce DNA damage, G2/M arrest and cell death in gastric cancer cell line
(2020-12-01)
Chronic inflammation resulting from Helicobacter pylori (H. pylori) infection, the major risk factor for gastric cancer, results in increased release of reactive oxygen species (ROS), promoting oxidative stress and DNA ...
Double-grafted chitosans as siRNA nanocarriers: effects of diisopropylethylamine substitution and labile-PEG coating
(Springer, 2022-03-31)
The preparation of safe and efficient siRNA carriers remains a challenge that has limited the therapeutic applications of siRNA. In this study, the design of a new small interfering RNA (siRNA) carrier based on ...
Estudo dos efeitos fisiopatológicos e moleculares do knockdown do gene CG15105 em cérebro de Drosophila melanogasterThe pathophysiological and molecular effects of CG15105 gene knockdown in Drosophila melanogaster brain
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Genética e Bioquímica, 2022)
Knockdown of host antioxidant defense genes enhances the effect of Glucantime on intracellular Leishmania braziliensis in Human Macrophages
(American Society for Microbiology, 2017)