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ANÁLISIS DE ASOCIACIÓN ENTRE POLIMORFISMOS DE UN SOLO NUCLEÓTIDO EN LOS GENES STAT 1, STAT 3, STAT 4 Y STAT 6 Y EL RIESGO A DESARROLLAR ASMA ALÉRGICA EN POBLACIÓN PEDIÁTRICA
(2009-11-18)
Introduction: Asthma is a chronic inflammatory airway disease, which affects
nearly the 15% of Mexican children. Increasing evidence shows that single
nucleotide polymorphisms (SNPs) in more than 100 candidate genes are ...
STAT5 transcriptional activity is impaired by LIF in a mammary epithelial cell line
(Academic Press Inc Elsevier Science, 2007-05)
Gene regulation mediated by STAT factors has been implicated in cellular functions with relevance to a variety of processes. Particularly, STAT5 and STAT3 play a crucial role in mammary epithelium displaying reciprocal ...
Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms
(Elsevier, 2017-04)
Zinc deficiency affects the development of the central nervous system (CNS) through mechanisms only partially understood. We previously showed that zinc deficiency causes CNS oxidative stress, damaging microtubules and ...
Activating mutations of STAT3: Impact on human growth
(Elsevier Ireland, 2020-12)
The signal transducer and activator of transcription (STAT) 3 is the most ubiquitous member of the STAT family and fulfills fundamental functions in immune and non-immune cells. Mutations in the STAT3 gene lead to different ...
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent
(2016)
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated inappropriately in a wide range of hematological and solid cancers, but clinically available therapies ...
Expresión de genes blanco de STAT3 en tejidos gingivales durante periodontitis experimental
(Universidad de Chile, 2022)
: La periodontitis es una enfermedad inflamatoria crónica, causada
por una disbiosis bacteriana y una respuesta inmune exagerada. Múltiples
citoquinas proinflamatorias están involucradas en la patogénesis de esta
enfermedad ...
Ciliary Neurotrophic Factor Protects Mice Against Streptozotocin-induced Type 1 Diabetes through SOCS3 THE ROLE OF STAT1/STAT3 RATIO IN beta-CELL DEATH
(Amer Soc Biochemistry Molecular Biology IncBethesdaEUA, 2012)
Activation of the regeneration-associated gene STAT3 and functional changes in intact nociceptors after peripheral nerve damage in mice
Background: In the context of neuropathic pain, the contribution of regeneration to the development of positive symptoms is not completely understood. Several efforts have been done to described changes in axotomized ...
Expressão de stat3 em tumor odontogênico queratocístico e ameloblastoma
(Faculdade de Odontologiaem Odontologia e SaúdeUFBAbrasil, 2016-08-23)
Stat3 é um fator de transcrição que está envolvido em diversos processos fisiológicos incluindo proliferação e sobrevivência celular. Expressão elevada da Stat3 tem sido encontrada em diversos tipos de neoplasias de mama, ...