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Gastric damage induced by different doses of indomethacin in rats is variably affected by inhibiting iNOS or leukocyte infiltration
(BIRKHAUSER VERLAG AG, 2008)
Aim: To evaluate the effect of inhibiting inducible nitric oxide synthase (iNOS), by aminoguanidine, or leukocyte infiltration, by fucoidin, on gastropathy induced by two different doses of indomethacin in rats. Methods: ...
Crucial role of neutrophils in the development of mechanical inflammatory hypernociception
(FEDERATION AMER SOC EXP BIOL, 2008)
Neutrophil migration is responsible for tissue damage observed in inflammatory diseases. Neutrophils are also implicated in inflammatory nociception, but mechanisms of their participation have not been elucidated. In the ...
Estudo químico da alga Lithothamnion calcareum e avaliação da atividade inibitória do rolamento de leucócitos
(Universidade Federal de Minas GeraisUFMG, 2009-02-19)
Lithothamnion calcareum (Hapaladiceae) is a marine alga found in deep waters, commercialized in Brazil and abroad as food supplement of calcium and other minerals. Polysaccharides have been reported as constituents of ...
IL-17 mediates articular hypernociception in antigen-induced arthritis in mice
(ELSEVIER SCIENCE BV, 2010)
IL-17 is an important cytokine in the physiopathology of rheumatoid arthritis (RA). However, its participation in the genesis of nociception during RA remains undetermined. In this study, we evaluated the role of IL-17 in ...
Neutrophil infiltration is implicated in the sustained thermal hyperalgesic response evoked by allergen provocation in actively sensitized rats
(Lippincott, Williams & Wilkins, 2020)
Peripheral P2x7 Receptor-induced Mechanical Hyperalgesia Is Mediated By Bradykinin
(Elsevier Ltd, 2014)