Folate pathway is a key target for the development of new drugs against infectious diseases since the discovery of sulfa drugs and trimethoprim. The knowledge about this pathway has increased in the last years and the ...

Folate, a B-group vitamin, is involved in many metabolic pathways such as energy usage, nucleic acid synthesis and one-carbon metabolism. Human beings cannot synthesize folate so an exogenous supply of this vitamin is ...

Folate intake during pregnancy is essential for an adequate fetal and placental development, as well as for the long-term health condition. Because folate deficiency may induce fetal pathologies, including neural tube ...

Individuals with Down syndrome (DS) carry three copies of the Cystathionine beta-synthase (C beta S) gene. The increase in the dosage of this gene results in an altered profile of metabolites involved in the folate pathway, ...

Acute lymphoblastic leukemia (ALL) is a frequent neoplasia occurring in children. The most commonly used drug for the treatment of ALL is methotrexate (MTX), an anti-folate agent. Previous studies suggest that folate ...

Recent researches have investigated the factors that determine the maternal risk for Down syndrome (DS) in young woman. In this context, some studies have demonstrated the association between polymorphisms in genes involved ...

Abstract Background Folate synthesis and salvage pathways are relatively well known from classical biochemistry and genetics but they have not been subjected to comparative genomic analysis. The availability of genome ...