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A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth
(Elsevier Ireland, 2016-02)
A family history of diabetes predisposes to gestational diabetes mellitus (GDM). We hypothesized that female offspring of rats with pre-gestational diabetes will develop GDM, a pathology associated with fetal overgrowth ...
Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2α signaling and increases fetal growth in rats.
(Society For The Study Of Reproduction, 2013-09)
The mammalian target of rapamycin (mTOR) and the eukaryotic initiation factor 2 (eIF2) signaling pathways control protein synthesis in response to nutrient availability. Moreover mTOR is a positive regulator of placental ...
Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming
(Wiley VCH Verlag, 2018-10)
Scope: Offspring from rats with mild diabetes develop gestational diabetes mellitus (GDM). We tested the hypothesis that an olive oil-supplemented diet attenuates placental oxidative stress/inflammation, activation of mTOR ...
PPARalpha agonists regulate lipid metabolism and nitric oxide production and prevents placental overgrowth in tern in placentas from diabetic rats
(BioScientifica, 2011-06)
Maternal diabetes impairs fetoplacental metabolism and growth. Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor capable of regulating lipid metabolism and inflammatory pathways. In this study, we ...
Intrauterine effects of impaired lipid homeostasis in pregnancy diseases
(Bentham Science Publishers, 2013-01)
Lipids are crucial structural and bioactive components that sustain embryo, fetal and placental development and growth. Intrauterine development can be disturbed by several diseases that impair maternal lipid homeostasis ...
Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPARγ and mTOR signaling in female offspring developing gestational diabetes
(Elsevier Science Inc, 2018-03)
Maternal diabetes impairs fetoplacental development and programs metabolic diseases in the offspring. We have previously reported that female offspring of pregnant rats with mild diabetes develop gestational diabetes ...
Adipokines underlie the early origins of obesity and associated metabolic comorbidities in the offspring of women with pregestational obesity
(2020)
Maternal pregestational obesity is a well-known risk factor for offspring obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes. The mechanisms by which maternal obesity can induce alterations in fetal ...
Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight
(Elsevier, 2017)
Use of glyburide in gestational diabetes (GDM) has raised concerns about fetal and neonatal side effects, including increased birth weight. Placental nutrient transport is a key determinant of fetal growth, however the ...
Adipokines underlie the early origins of obesity and associated metabolic comorbidities in the offspring of women with pregestational obesity
(Elsevier, 2020)
Maternal pregestational obesity is a well-known risk factor for offspring obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes. The mechanisms by which maternal obesity can induce alterations in fetal ...
Factores maternos y ganancia de peso en un grupo de gestantes con recién nacidos macrosómicosMaternal Factors and Weight Gain in a Group of Pregnant Women with Macrosomic Newborns
(Universidad de Antioquia, Escuela de Nutrición y DietéticaAlimentación y Nutrición HumanaMedellín, Colombia, 2022)