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Clinicopathological significance of ERCC1 expression in breast cancer
(2013-06-01)
The excision repair cross-complementation 1 (ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway and is associated with resistance to platinum-based chemotherapy in different types of cancer. ...
Clinicopathological significance of ERCC1 expression in breast cancer
(2013-06-01)
The excision repair cross-complementation 1 (ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway and is associated with resistance to platinum-based chemotherapy in different types of cancer. ...
DNA repair kinetic of hydrogen peroxide and UVA/B induced lesions in peripheral blood leucocytes from xeroderma pigmentosum patients and healthy subjects
(Begell House Inc, 2014-11)
The objective of the present work was to study the fine kinetics of DNA repair in xeroderma pigmentosum (XP) syndrome, a complex disorder linked to a deficiency in repair that increases cancer susceptibility. The repair ...
Coupling between nucleotide excision repair and gene expression
(Taylor & Francis, 2018-07)
Gene expression and DNA repair are fundamental processes for life. During the last decade, accumulating experimental evidence point towards different modes of coupling between these processes. Here we discuss the molecular ...
DNA repair mechanisms protect our genome from carcinogenesis
(FRONTIERS IN BIOSCIENCE INCIRVINE, 2012)
Human cells are constantly exposed to DNA damage. Without repair, damage can result in genetic instability and eventually cancer. The strong association between the lack of DNA damage repair, mutations and cancer is ...
Genetic variability and DNA repair: base excision repair activities in Helicobacter pylori .
(American Scientific Publishers, 2003-03)
One of the remarkable characteristics of Helicobacter pylori is the high genetic diversity it displays. Based on the genome sequencing results, the absence of certain DNA repair activities has been postulated to be one of ...
Expression of 8-oxoguanine Glycosylase in Human Fetal Membranes
(Wiley-Blackwell, 2014-07-01)
Problem The most common DNA lesion generated by oxidative stress (OS) is 7, 8-dihydro-8-oxoguanine (8-oxoG) whose excision repair is performed by 8-oxoguanine glycosylase (OGG1). We investigated OGG1 expression changes in ...