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Peptidomic Analysis of HEK293T Cells: Effect of the Proteasome Inhibitor Epoxomicin on Intracellular Peptides
(AMER CHEMICAL SOCWASHINGTON, 2012)
Peptides derived from cytosolic, mitochondrial, and nuclear proteins have been detected in extracts of animal tissues and cell lines. To test whether the proteasome is involved in their formation, HEK293T cells were treated ...
Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells
(Mdpi, 2019-06-01)
Peptides produced by the proteasome have been proposed to function as signaling molecules that regulate a number of biological processes. In the current study, we used quantitative peptidomics to test whether conditions ...
Peptidomic Analysis of HEK293T Cells: Effect of the Proteasome Inhibitor Epoxomicin on Intracellular Peptides
(Amer Chemical SocWashington, 2012)
Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells
(Facultad de Medicina y CienciaCentro de Biología Celular y Biomedicina CEBICEM, 2019)
Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated. Centrosome re-orientation to the ...
PROTEASOME ACTIVITY AND ITS RELATIONSHIP WITH PROTEIN PHOSPHORYLATION DURING CAPACITATION AND ACROSOME REACTION IN HUMAN SPERMATOZOA
(S/EDITORIAL, 2007)
We have shown that the proteasome is present in mammalian sperm and plays a role during fertilisation. In this work we studied the relationship between protein phosphorylation and proteasomal activity in human sperm. ...
Analysis of the Yeast Peptidome and Comparison with the Human Peptidome
(Public Library Science, 2016-09-29)
Peptides function as signaling molecules in species as diverse as humans and yeast. Mass spectrometry-based peptidomics techniques provide a relatively unbiased method to assess the peptidome of biological samples. In the ...
Reduced levels of proteasome products in a mouse striatal cell model of huntington's disease
(2015-12-01)
Huntington's disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular changes and ultimately results in neurodegeneration of striatal ...
Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib
(Public Library ScienceSan FranciscoEUA, 2013)