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Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation
(2012)
The first step in the penicillin biosynthetic pathway is the non-ribosomal condensation of l-α-aminoadipic acid, l-cysteine and l-valine into the tripeptide δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine (ACV). This reaction is ...
Expressão de epimerase de dermatam sulfato em linhagens de câncer de mama
(Universidade Federal de São Paulo (UNIFESP), 2019-05-30)
Breast cancer is one of the most incident cancers in the world population, especially in the female population. Estimates show that more than 1.7 million new cases are registered each year and 522,000 are killed. By the ...
Structure, kinetic characterization and subcellular localization of the two ribulose 5-phosphate epimerase isoenzymes from Trypanosoma cruzi
(Public Library of Science, 2017-02)
The enzyme of the pentose phosphate pathway (PPP) ribulose-5-phosphate-epimerase (RPE) is encoded by two genes present in the genome of Trypanosoma cruzi CL Brener clone: TcRPE1 and TcRPE2. Despite high sequence similarity ...
Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 Å resolution
(1995-12-01)
Background: Glucosamine 6-phosphate deaminase from Escherichia coli is an allosteric hexameric enzyme which catalyzes the reversible conversion of D-glucosamine 6-phosphate into D-fructose 6-phosphate and ammonium ion and ...
Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 Å resolution
(1995-12-01)
Background: Glucosamine 6-phosphate deaminase from Escherichia coli is an allosteric hexameric enzyme which catalyzes the reversible conversion of D-glucosamine 6-phosphate into D-fructose 6-phosphate and ammonium ion and ...
XAC4296: A multidomain and exclusive Xanthomonadaceae protein related to chromosome segregation, cell division, and bacterial fitness
(Universidade Estadual Paulista (Unesp), 2022-05-13)
Os micro-organismos apresentam um repertório limitado e extremamente adaptável de genes. Muitos destes genes codificam para proteínas contendo um único domínio ou multidomínios proteicos variáveis, sendo que em ambos os ...
Gene expression and enzyme activities of the D-mannose/L-galactose pathway influence L-ascorbic acid content in Myrciaria dubia
(Springer NatureChequia, 2015-12)
The aim of this work was to elucidate the molecular and biochemical mechanisms that control L-ascorbic acid (AsA) content variation in Myrciaria dubia. The AsA was quantified by high-performance liquid chromatography, gene ...
Avaliação da expressão de UDP Glicose 4-Epimerase e β-1,4-galactosiltransferase III no câncer gástrico e sua possível associação com parâmetros clínico-patológicos e de desfecho
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Ciencias Biologicas, 2019)