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EFFECTS of ENDOTHELIN-3 ON the ISOLATED GUINEA-PIG ILEUM - ROLE of NA+ IONS and ENDOTHELIN RECEPTOR SUBTYPES
(Elsevier B.V., 1992-04-22)
Endothelin-3 induced a relaxation followed by contraction in the isolated guinea-pig ileum. the contractile but not the relaxant component of the response was concentration-dependent in the dose range studied. Neuronal ...
ROLE of POSITION-9 and POSITION-10 in the ENDOTHELIN MOLECULE for BIOLOGICAL-ACTIVITY and DISCRIMINATION of RECEPTOR SUBTYPES
(Elsevier B.V., 1995-05-15)
The importance of residues 9 and 10 in endothelin-1 was assessed by studying the responses of the guinea-pig ileum to [Ala(9)]endothelin-1 and [Ala(10)]endothelin-1. Both analogues induced relaxation followed by contraction. ...
HETEROGENOUS ENDOTHELIN RECEPTORS MEDIATE RELAXATION and CONTRACTION in the GUINEA-PIG ILEUM
(Elsevier B.V., 1995-10-24)
IRL1620, a specific endothelin ET(B) receptor agonist, induced relaxation followed by contraction in the guinea-pig ileum, as did endothelin-1. Both components of the response were concentration-dependent in the range ...
Effects of endothelin ETB receptor agonists and antagonists on the biphasic response in the ileum
(Elsevier B.V., 1999-03-19)
In the guinea-pig ileum, both sarafotoxin S6c and IRL1620 (Suc-[Glu(9),Ala(11,15)]endothelin-1-(8-21) induced a concentration-dependent biphasic effect (relaxation and contraction), but distinct tachyphylaxis of the tissue. ...
Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL1620 in the ileum
(Lippincott Williams & Wilkins, 1998-01-01)
In the guinea pig ileum, both sarafotoxin S6c (S6c) and IRL1620 induced a biphasic effect (relaxation and contraction). S6c induced strong tachyphylaxis of both components of the response, but IRL1620 induced tachyphylaxis ...
CHARACTERIZATION OF FUNCTIONAL ENDOTHELIN RECEPTORS IN THE CANINE ISOLATED-PERFUSED SPLEEN
(Elsevier Science BvAmsterdamHolanda, 1995)