Buscar
Mostrando ítems 1-10 de 137
The Druggable Pocketome of Corynebacterium diphtheriae: A New Approach for in silico Putative Druggable Targets
(Frontiers Media Sa, 2018-02-13)
Diphtheria is an acute and highly infectious disease, previously regarded as endemic in nature but vaccine-preventable, is caused by Corynebacterium diphtheriae (Cd). In this work, we used an in silico approach along the ...
A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data
(Biomed Central Ltd., 2010-12-22)
Background: The genome-wide identification of both morbid genes, i.e., those genes whose mutations cause hereditary human diseases, and druggable genes, i.e., genes coding for proteins whose modulation by small molecules ...
A machine learning approach for genome-wide prediction of morbid and druggable human genes based on systems-level data
(Biomed Central Ltd., 2010-12-22)
Background: The genome-wide identification of both morbid genes, i.e., those genes whose mutations cause hereditary human diseases, and druggable genes, i.e., genes coding for proteins whose modulation by small molecules ...
The druggable pocketome of Corynebacterium diphtheriae: A new approach for in silico putative druggable targets
(Frontiers Research Foundation, 2018-02)
Diphtheria is an acute and highly infectious disease, previously regarded as endemic in nature but vaccine-preventable, is caused by Corynebacterium diphtheriae (Cd). In this work, we used an in silico approach along the ...
Prediction of Druggable Proteins Using Machine Learning and Systems Biology: A Mini-Review
(Frontiers Media Sa, 2015-12-08)
The emergence of -omics technologies has allowed the collection of vast amounts of data on biological systems. Although, the pace of such collection has been exponential, the impact of these data remains small on many ...
Prediction of druggable proteins using machine learning and systems biology: A mini-review
(2015-01-01)
The emergence of -omics technologies has allowed the collection of vast amounts of data on biological systems. Although, the pace of such collection has been exponential, the impact of these data remains small on many ...
Functional and druggability analysis of the SARS-CoV-2 proteome
(Cold Spring Harbor Laboratory, 2020-08-22)
The infectious coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, appeared in December 2019 in Wuhan, China, and has spread worldwide. As of today, more than 22 million people have been infected, ...
An integrated structural proteomics approach along the druggable genome of Corynebacterium pseudotuberculosis species for putative druggable targets
(BioMed Central, 2015-05)
Background: The bacterium Corynebacterium pseudotuberculosis (Cp) causes caseous lymphadenitis (CLA), mastitis, ulcerative lymphangitis, and oedema in a number of hosts, comprising ruminants, thereby intimidating economic ...