Buscar
Mostrando ítems 1-10 de 231
Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
(Springer, 2013-01)
Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their rapid and abundant induction by stress. HSP genes are activated at the transcriptional level by heat shock transcription factor 1 ...
De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock
(Wiley-Blackwell, 2013-01-01)
BackgroundMortality rates among patients with sepsis, severe sepsis or septic shock are highly variable throughout different regions or services and can be upwards of 50%. Empirical broad-spectrum antimicrobial treatment ...
Treatment of pulmonary thromboembolism in patients with systemic blood pressure stability and right ventricular dysfunction
(2008-02-01)
Pulmonary thromboembolism (PTE) ranges from incidental, clinically unimportant thromboembolism to massive embolism with sudden death. Its treatment is well established in two groups of patients: heparin for those with ...
Treatment of pulmonary thromboembolism in patients with systemic blood pressure stability and right ventricular dysfunction
(2008-02-01)
Pulmonary thromboembolism (PTE) ranges from incidental, clinically unimportant thromboembolism to massive embolism with sudden death. Its treatment is well established in two groups of patients: heparin for those with ...
Molecular approaches to target heat shock proteins for cancer treatment
(Bentham Science Publishers, 2015)
HSP90 was the first molecular target to inhibit the interaction of this heat shock protein (HSP) with client proteins in cancer cells and tissues. The HSP90 inhibition was attempted to liberate from this chaperone the ...
Management of septic shock with a norepinephrine-based haemodynamic algorithm
(ELSEVIER IRELAND LTD, 2005)
Management of septic shock (SS) with a norepinephrine (noradrenaline)-based haemodynamic algorithm. Introduction: The choice of the best vasopressor for haemodynamic management of septic shock is controversial. Nevertheless, ...
Heat shock protein 27 modulates autophagy and promotes cell survival after photodynamic therapy
(Royal Society of Chemistry, 2019-02)
Photodynamic therapy (PDT) is a clinically approved treatment that exerts a selective cytotoxic activity toward cancer cells. The procedure involves the administration of a photosensitizer drug followed by its activation ...
Current use of inotropes in circulatory shock
(2021)
Abstract
Background
Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, ...