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Effect of inhalation exposure to toluene on the activity of organic anion transporting polypeptide (Oatp) using pravastatin as a probe drug in rats
(2018-07-03)
1. Toluene, used as a pure substance or in solvent mixtures, is the cause of occupational exposures of large numbers of workers in the world. The organic anion transporting polypeptides (OATP: human; Oatp: rodents) are ...
EXPOSICAO DE CIRURGIOES-DENTISTAS AO MERCURIO
(1981-12-01)
The professional exposure of dental surgeons to mercury has attracted a great deal of attention from governmental organs and institutions in different countries. Considering that the normal ratio is 10 μg/1000 ml of urine, ...
EXPOSICAO DE CIRURGIOES-DENTISTAS AO MERCURIO
(1981-12-01)
The professional exposure of dental surgeons to mercury has attracted a great deal of attention from governmental organs and institutions in different countries. Considering that the normal ratio is 10 μg/1000 ml of urine, ...
Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A review of animal studies
(Blackwell Publishing Inc., 2019)
Host pharmacokinetics and drug accumulation of anthelmintics within target helminth parasites of ruminants
(New Zealand Veterinary Assoc Inc, 2017-07)
Anthelmintic drugs require effective concentrations to be attained at the site of parasite location for a certain period to assure their efficacy. The processes of absorption, distribution, metabolism and excretion ...
Neonatal rat exposure to pyrethroid and organophosphate insecticides: A physiological and biochemical trial of progeny
(2004-10-14)
A manufactured product (Ectoplus®) composed by a cypermethrin (44.7%) and dichlorvos (4.2%) mixture was administered (10mg/kg/day, orally, by gavage) to pregnant rats, during the periods of gestation+lactation, gestation, ...
Neonatal rat exposure to pyrethroid and organophosphate insecticides: A physiological and biochemical trial of progeny
(2004-10-14)
A manufactured product (Ectoplus®) composed by a cypermethrin (44.7%) and dichlorvos (4.2%) mixture was administered (10mg/kg/day, orally, by gavage) to pregnant rats, during the periods of gestation+lactation, gestation, ...
Enzyme Induction and Drug Metabolism
(Springer Nature Switzerland AG, 2021)
Enzyme induction is one of the most important underlying mechanism of drug-drug interactions (DDIs). It can be defined as an increase in the biosynthesis of metabolizing enzymes after the exposure of the organism to ...