Pegylation technologies have improved since chemistry and purification processes have advanced over the years. Furthermore, a gradual better understanding of the clinical responses has spurred the need for more effective ...

Antibody drug conjugates (ADCs) normally compose of a humanized antibody and small molecular drug via a chemical linker. After decades of preclinical and clinical studies, a series of ADCs have been widely used for ...

Photodynamic therapy (PDT) is based on the cytotoxicity of photosensitizers in the presence of light. Increased selectivity and effectivity of the treatment is expected if a specific uptake of the photosensitizers into the ...

In recent years, the popular term "polymer-drug conjugate" has been introduced to describe new drug targets to combat diseases such as cancer. Due to its potential benefits in terms of human health, this concept has managed ...

In recent years, the popular term "polymer-drug conjugate" has been introduced to describe new drug targets to combat diseases such as cancer. Due to its potential benefits in terms of human health, this concept has managed ...

Background: Aminoquinoline/steroid conjugates were synthesized based on the fact that steroid transporters have been shown to accept and carry a variety of drugs. So, in continuing our research of antileishmanial and ...

The brain is partially protected from chemical insults by a physical barrier mainly formed by the cerebral microvasculature, which prevents penetration of hydrophilic molecules in the cerebral extracellular space. This ...

Ligand-based targeting of the receptors that are overexpressed explicitly on cancer cells represents an effective drug delivery approach to enhance the chemotherapeutic efficacy. Proprotein convertase subtilisin/kexin type ...