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Stereoselective synthesis of the dolastatin units by organotrifluoroborates additions to alpha-amino aldehydes
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Dolastatin units were synthesized from the 1,2-addition reactions of potassium allyl or crotyltrifluoroborate salts to aldehyde derivatives from natural amino acids. The reactions were carried out in presence of a ...
An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis-Hillman reaction
(Pergamon-elsevier Science LtdOxfordInglaterra, 2003)
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
Búsqueda de posibles compuestos con actividad insecticida a partir de cianobacterias del Caribe colombiano
(2017)
Resumen: Se estudiaron tres mats de cianobacterias usando fraccionamiento bioguiado con el ensayo larvicida contra Aedes aegypti. Como compuestos activos se aislaron ácidos grasos insaturados, dos nuevos análogos de ...
Estudos visando a síntese total da Isodolastatina H
(Universidade Federal de São Paulo (UNIFESP), 2008-02-27)
This dissertation, are described the study towards to total synthesis of isodolastatin H, a natural peptide ester of dolastatin family with great citotoxicity activity. The main focus in this synthesis, is the construction ...
Búsqueda de compuestos con posible actividad insecticida a partir de cianobacterias del Caribe colombiano
(2017-05-26)
Se estudiaron tres mats de cianobacterias usando fraccionamiento bioguiado con el ensayo larvicida contra Aedes aegypti. Como compuestos activos se aislaron ácidos grasos insaturados, dos nuevos análogos de dolastatina D ...