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Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia
Background The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes (“enhanceosomes”) that upregulate expression of select genes ...
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
Molecular hybridization: A useful tool in the design of new drug prototypes
(2007-07-01)
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
Karyotype analysis of interspecific hybrids between haliotis rufescens and haliotis discus hannai
(WILEY-BLACKWELL, 2011)
Evidence of hybridization in Haliotis has been mainly supported by hatchery experiences and collection of wild hybrid abalones among several species from natural populations worldwide. However, despite the importance to ...
Karyotype characterization, constitutive heterochromatin and nucleolus organizer regions of Paranaita opima (Coleoptera, Chrysomelidae, Alticinae)
(Sociedade Brasileira de Genética, 2006-01-01)
Species of the subtribe Oedionychina not only have a highly uniform diploid number of 2n = 22 (20+X+y) but have the karyotypic peculiarity of possessing extremely large sex chromosomes. We analyzed Paranaita opima embryos ...
Toward encoding reactivity using double-stranded DNA. Sequencedependent native chemical ligation of DNA binding polyamides
(Elsevier, 2013-06)
The coupling reaction between distamycin-related polyamides equipped with cysteine and thioester groups can be accelerated in the presence of double-stranded (ds) oligonucleotides with selected sequences. While the coupling ...
Inhibition Of Poly(2′fluoro-2′deoxyadenylic Acid)-directed-reverse Transcriptase Actmty
(Informa Healthcare, 1995)
Synthesis, Structure, and Phosphatase-Like Activity of a New Trinuclear Gd Complex with the Unsymmetrical Ligand H(3)L As a Model for Nucleases
(AMER CHEMICAL SOC, 2010)
The new trinuclear gadolinium complex [Gd(3)L(2)(NO(3))(2)(H(2)O)(4)]NO(3)center dot 8H(2)O (1) with the unsymmetrical ligand 2-[N-bis-(2-pyridylmethyl)aminomethyl]-4-methyl-6-[N-bis(2-hydroxy-2-oxoethyl)aminomethyl] phenol ...
Efficient Phosphodiester Hydrolysis by Luminescent Terbium(III) and Europium(III) Complexes
(AMER CHEMICAL SOC, 2010)
The synthesis and structures of two new isostructural mononuclear [Ln(L)(NO(3))(H(2)O)(3)](NO(3))(2) complexes, with Ln = Tb (complex 1) and Eu (complex 2), which display high activity in the hydrolysis of the substrate ...