Buscar
Mostrando ítems 1-10 de 118
Easy synthesis of new series of pteridine analogs: di- and tetra-hydropyrimido[4,5-d]pyrimidines via 5-pyrimidinecarbaldehydes
(Arkat USA, 2014-04)
Pyrimidine-5-carbaldehyde derivatives, of easy access, were selected as precursors for the synthesis of mimic pteridine derivatives 5,6-dihydropyrimido[4,5-d]pyrimidines and 5,6,7,8- tetrahydropyrimido[4,5-d]pyrimidines ...
Síntese de compostos contendo núcleos de pirimidínicos derivados de β-enaminodicetonas
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2019-03-22)
In this work the reactivity of β-enaminodiketones [RC(O)C(=CHNMe2)C(O)R1], (wher R= C6H5, 4-Me-C6H4, 4-OMe-C6H4, 4-Cl-C6H4 4-NO2-C6H4, thien-2-yl and furan-2-yl) and R1 (CF3 and CO2Et), was studied with dinucleophiles such ...
Síntese e aplicação de pirazóis na construção de poliheterociclos com potencial bioatividade
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2022-09-06)
This work reports the synthesis of eight series of substituted trifluoromethyl
heterocycle compounds, based on the synthetic versatility and regioselectivity of 4-
alkoxy(amino)-5-bromo-1,1,1-trifluorpent-3-en-2-ones in ...
1,n-Diamines. Part 3: Microwave-assisted synthesis of N-acyl-N′-arylhexahydropyrimidines and hexahydro-1,3-diazepines
(Pergamon-Elsevier Science Ltd, 2011-10)
In this Letter we present a method for the synthesis of N-acyl-N´-arylhexahydropyrimidines 1, by ring closure of N-acyl-N´-aryl-1,3-propanediamines 3 with formaldehyde. Cyclodehydrations were performed in aqueous medium ...
One-Step Synthesis of Fully Functionalized Pyrazolo[3,4-b]pyridines via Isobenzofuranone Ring Opening
(American Chemical Society, 2017-12)
A novel series of fully substituted pyrazolo[3,4-b]pyridines 4 has been prepared in a regioselective manner by the microwave-assisted reaction between N-substituted 5-aminopyrazoles 1 and 3-(3-oxo-2-benzofuran-1(3H)-ylid ...
Uso de microondas na síntese de 3-alquil(aril)-5-hidróxi-5-triclorometil-4,5-diidro-1h-pirazol-1-carboxiamida
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2005-03-01)
A series of 3-alkyl and 3-aryl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1Hpirazoles-1-carboxiamide that possess biological activity they were synthesized, in good yeld, through the cyclocondensation, in microwaves, of ...
Síntese regiosseletiva de novas (4,5-diidropirazol-1-il)(-pirimidin-4-il)metanonas com potencial farmacológico
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2016-10-20)
This study shows the synthesis of five new 6-substituted 2-methylthio-4-pyrimidine carbohydrazides, aryl groups having such substituents (Ph, 4-FC6H4, 4-BrC6H4, 4-MeC6H4, 4-MeOC6H4) from the nucleophilic substitution of ...
Síntese de 3-haloacetil-4-metilquinolinas utilizando líquido iônico sob irradiação de micro-ondas
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2011-07-27)
The synthesis of a series of 3-haloacetyl-4-methyl-quinolines from the
cyclocondensation reaction of 4-alkoxyvinyl ketones [R1C(O)CH=C(R2)(OCH3),
where R1 = CF3, CCl3, CHCl2, CF2Cl, CF2CF3 and R2 = Me, Et, Pr, Bu, i-Bu, ...
Microwave-induced Synthesis of N-Substituted 1-Alkyl and 1-Aryl 3-Aminoisoquinolines
(Bentham Science Publishers, 2017-03)
Background: Aminoisoquinolines are an important class of heterocyclic compounds. These compounds present a wide range of pharmacological properties including antimalaric, anticonvulsant and anti-inflammatory. Although ...