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Skin is the most frequently damaged system in recent-onset systemic lupus erythematosus in a tropical region
(Springer, 2005-08-01)
The objective of this study was to evaluate the early damage as measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI) in Brazilian systemic lupus ...
Pseudoxanthoma Elasticum: An Interesting Model to Evaluate Chronic Kidney Disease-Like Vascular Damage without Renal Disease
(Karger Publishers Open Access, 2020)
Background: Pseudoxanthoma elasticum (PXE; OMIM
264800) is an inherited multisystem disorder associated with
accumulation of mineralized and fragmented elastic fibers
in the skin, vascular walls, and brush membrane in ...
Probiotic effects on skin health: the case of photoprotection as a model of gut-skin dialog
(Springer Nature Switzerland AG, 2021)
The skin is the most external organ of our body, and it is constantly exposed to environmental challenges. In this way, ultraviolet radiation (UVr) contained within sunlight is one of the most important insults that our ...
Acute Sun Damage and Photoprotective Responses in Whales
(Proceeding of the Royal Society B-Biological Sciences, 2011)
Rising levels of ultraviolet radiation (UVR) secondary to ozone depletion are an issue of concern for public health. Skin cancers and intraepidermal dysplasia are increasingly observed in individuals that undergo chronic ...
Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation
(Elsevier Ireland, 2020-11)
Skin exposure to ultraviolet B (UVB) radiation leads to local oxidative stress, inflammation, systemic immunosuppression and, ultimately, the development of skin cancer. Metformin is the most prescribed drug for type 2 ...
Cutaneous wound healing: An update from physiopathology to current therapies
(2021-07-01)
The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this barrier is damaged, the organism promotes the healing process with several molecular and cellular mechanisms, ...
Exploratory Study of Epidermis, Basement Membrane Zone, Upper Dermis Alterations and Wnt Pathway Activation in Melasma Compared to Adjacent and Retroauricular Skin
(Korean Dermatological Assoc, 2020-04-01)
Background: Melasma is a chronic acquired focal hyper-melanosis which pathogenesis has not been fully elucidated. Classical pathophysiologic studies have analysed the affected and perilesional areas, but little is known ...
Atopic dermatitis: correlation between non-damaged skin barrier function and disease activity
(WILEY-BLACKWELLHOBOKEN, 2012)
Background Atopic dermatitis (AD) is a chronic dermatosis, predominant in childhood, characterized by pruritus and eczematous-type lesions with xerosis as the prominent clinical sign. Objectives To analyze the correlation ...