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Pharmacotherapies for Parkinson’s disease symptoms related to cholinergic degeneration
(Informa Healthcare, 2016-10)
Introduction: Dopamine depletion is one of the most important features of Parkinson’s Disease (PD). However, insufficient response to dopaminergic replacement therapy suggests the involvement of other neurotransmitter ...
Pharmacotherapies for parkinson's disease symptoms related to cholinergic degeneration
(Taylor & Francis, 2022)
The Cholinergic System in Mild Cognitive Impairment and Alzheimer`s Disease: An In Vivo MRI and DTI study
(WILEY-BLACKWELL, 2011)
Few studies have investigated in vivo changes of the cholinergic basal forebrain in Alzheimer`s disease (AD) and amnestic mild cognitive impairment (MCI), an at risk stage of AD. Even less is known about alterations of ...
Neuropsychiatric symptoms related to cholinergic deficits in Parkinson’s disease
(Springer Nature, 2017)
Abstract: Given its ability to explain the most frequent motor symptoms of Parkinson’s disease (PD), degeneration of dopaminergic neurons has been considered one of the disease´s main pathophysiological features. Several ...
Increased Cholinergic Tone Causes Pre-synaptic Neuromuscular Degeneration and is Associated with Impaired Diaphragm Function
(2021-04-15)
In vertebrates, muscle activity is dependent on acetylcholine (ACh) released from neuromuscular junctions (NMJs), and changes in cholinergic neurotransmission are linked to a variety of neuromuscular diseases, including ...
Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson’s disease
(Parkinson's Disease FoundationMacmillan Publishers Limited, 2016)
Abstract: In view of its ability to explain the most frequent motor symptoms of Parkinson’s Disease (PD), degeneration of dopaminergic neurons has been considered one of the disease’s main pathophysiological features. ...
Reduction of an afterhyperpolarization current increases excitability in striatal cholinergic interneurons in rat parkinsonism
(Society for Neuroscience, 2011-04)
Striatal cholinergic interneurons show tonic spiking activity in the intact and sliced brain, which stems from intrinsic mechanisms. Because of it, they are also known as "tonically active neurons" (TANs). Another hallmark ...
What’s wrong with the striatal cholinergic interneurons in Parkinson’s disease? Focus on intrinsic excitability
(Wiley Blackwell Publishing, Inc, 2020-04)
Parkinson's disease (PD) is characterized by a degeneration of nigrostriatal dopaminergic neurons that results in a hypercholinergic state in the striatum. This hypercholinergic state contributes to the clinical signs of ...
Enhanced airways responsiveness in rats depleted of sensory neuropeptides by neonatal capsaicin treatment
(Elsevier Sci Ireland LtdClareIrlanda, 2003)
Impact of the NGF Maturation and Degradation Pathway on the Cortical Cholinergic System Phenotype
(Society for Neuroscience, 2012-02)
Cortical cholinergic atrophy plays a significant role in the cognitive loss seen with aging and in Alzheimer's disease (AD), but the mechanisms leading to it remain unresolved. Nerve growth factor (NGF) is the neurotrophin ...