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Clonagem e expressão de anticorpo monoclonal anti-CD20 recombinante: primeiros passos para desenvolvimento de novos anticorpos terapêuticos contra o câncer
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
Biosimilar monoclonal antibodies in Latin America
(IntechOpen, 2021)
Antibodies, also known as immunoglobulins, are complex glycoproteins produced by B-cells against foreign substances as part of the adaptive immune response [1, 2]. The invention of the hybridoma technology in 1975 by Köhler ...
A Critical Review of Properties and Analytical/Bioanalytical Methods for Characterization of Cetuximab
(2019-01-01)
Cetuximab (CTX) is a chimeric monoclonal antibody (mAb) able to selectively bind to the epidermal growth factor receptor (EGFR), resulting in inhibition of EGF linkage and phosphorylation cascade interruption. As a result, ...
Modulators of complement activation: a patent review (2008 - 2013)
(Informa Healthcare, 2014-03)
Introduction: The architecture of the complement system has evolved during the last 600 – 700 million years to become an amazingly efficient and highly versatile alerting and cell killing device. Under physiological ...
Uso del rituximab(anticuerpo monoclonal anti-CD20) en lupus eritematoso sistémico refractario a tratamiento: Caso clínico
(Sociedad Médica de Santiago, 2005)
Genetic engineering of antibody molecules
(Wiley VCH Verlag, 2015)
Antibodies are proteins produced by the immune system to combat pathogens and have long been appreciated for their exquisite specificity. The development of the hybridoma technology made it possible to immortalize single ...
Replacement of the V3 Domain in the Surface Subunit of the Feline Immunodeficiency Virus Envelope Glycoprotein with the Equivalent Region of a T Cell-Tropic Human Immunodeficiency Virus Type 1 Results in a Chimeric Surface Protein That Efficiently Binds to CXCR4
(Universidad de Belgrano - Facultad de Ciencias Exactas y Naturales - Proyectos de Investigación, 2014)
Feline immunodeficiency virus (FIV) and the T cell-tropic strains of human immunodeficiency virus type 1 (HIV-1) share the use of the chemokine receptor CXCR4 for cell entry. To study this process further we developed a ...
Hemofilia adquirida tratada con anti-CD20, un anticuerpo anti linfocito B
(SOC MEDICA SANTIAGO, 2011-03)
We report a 54-year-old male presenting with a history or recurrent nose bleeds
and ecchymoses. The coagulation study showed a prolonged partial thromboplastin
time, a factor VIII of 8% and a high inhibitor titer (193 ...
Hemofilia adquirida tratada con anti CD20, un anticuerpo anti linfocito B
(Sociedad Médica de Santiago, 2011)
Nuevas armas inmunológicas para la medicina del siglo XXI: Terapia biológica basada en el uso de anticuerpos monoclonales de última generación
(Sociedad Médica de Santiago, 2003)
The fusion of a murine B cell and a myeloma cell generates a hybridoma that
produces monoclonal antibody (mAb). These murine mAb induce the HAMA (human anti-mouse
antibodies) response. Murine mAb have been modified by ...