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Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L
(Walter de Gruyter & Co, 2005-11-01)
The S-1 and S-2 subsite specificity of recombinant human cathepsins X was studied using fluorescence resonance energy transfer (FRET) peptides with the general sequences Abz-Phe-Xaa-Lys(Dnp)-OH and Abz-XaaArg-Lys(Dnp)-OH, ...
Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor
(Walter de Gruyter Gmbh, 2010-05-01)
Plasminogen is a glycoprotein implicated in angiogenesis and fibrin clot degradation associated with the release of angiostatin and plasmin activation, respectively We have recently reported that cathepsin V. but not ...
Defining the substrate specificity of mouse cathepsin P
(Elsevier B.V., 2005-03-01)
Cathepsin P is a recently discovered placental cysteine protease that is structurally related to the more ubiquitously expressed, broad-specificity enzyme, cathepsin L. We studied the substrate specificity requirements of ...
Cathepsin X binds to cell surface heparan sulfate proteoglycans
(Elsevier B.V., 2005-04-15)
Glycosaminoglycans have been shown to be important regulators of activity of several papain-like cathepsins. Binding of glycosaminoglycans to cathepsins thus directly affects catalytic activity, stability or the rate of ...
Cyclic, Linear, Cycloretro-Isomer, and Cycloretro-Inverso Peptides Derived from the C-Terminal Sequence of Bradykinin as Substrates or Inhibitors of Serine and Cysteine Proteases
(Springer, 2004-05-01)
We investigated the inhibition of trypsin, human tissue (hK1) and human plasma kallikrein (HuPK), papain, and cathepsin L, B, and X by synthetic cyclic, cycloretro-isomer, cycloretro-inverso, and linear peptides derived ...
Corneal angiogenesis modulation by cysteine cathepsins: in vitro and in vivo studies
(Elsevier B.V., 2015-05-01)
Corneal avascularization is essential for normal vision. Several antiangiogenic factors were identified in cornea such as endostatin and angiostatin. Cathepsin V, which is highly expressed in the cornea, can hydrolyze human ...
Purification and partial characterization of cathepsin D from porcine (Sus scrofa) liver using affinity chromatography
(Academic Press Aust, 1998-07-01)
Cathepsin D, a lysosomal aspartic protease, has been purified from porcine liver using a combination of pepstatin-A agarose and Affi-Gel Blue affinity chromatography, followed by size-exclusion chromatography. The purified ...
A possible alternative mechanism of kinin generation in vivo by cathepsin L
(Walter de Gruyter & Co, 2005-07-01)
We investigated the ability of cathepsin L to induce a hypotensive effect after intravenous injection in rats and correlated this decrease in blood pressure with kinin generation. Simultaneously with blood pressure decrease, ...
Inhibitory effect of the sugarcane cystatin CaneCPI-4 on cathepsins B and L and human breast cancer cell invasion
(Walter de Gruyter & Co, 2008-04-01)
The lysosomal cysteine proteases cathepsin B and L play important roles in tumor cell invasion. An imbalance between these cathepsins and their endogenous inhibitors, the cystatins, has been associated with development of ...