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Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro
(LIPPINCOTT WILLIAMS & WILKINS, 2010)
Background Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the ...
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction
(Wiley-BlackwellOxford, 2013-10-08)
BACKGROUND:
Ischemia and reperfusion (IR) injury remains a major cause of morbidity and mortality and multiple molecular and cellular pathways have been implicated in this injury. We determined whether acute inhibition ...
Low-dose Enalapril Reduces Angiotensin II and Attenuates Diabetic-induced Cardiac and Autonomic Dysfunctions
(LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA, 2012)
Activation of renin-angiotensin system has been linked to cardiovascular and autonomic dysfunctions in diabetes. Experiments were performed to investigate the effects of angiotensin-converting enzyme inhibitor (ACEI), ...
Regulation of the Cardiac Sodium/Bicarbonate cotransporter by Angiotensin II: potential contribution to structural, ionic and electrophysiological Myocardial remodelling
(Bentham Science Publishers, 2013-02)
The sodium/ bicarbonate cotransporter (NBC) is, with the Na+ /H+ exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pHi). In the heart exists at least three isoforms of NBC, one ...
Inhibition of the Sodium-Glucose Co-Transporter Protein Type 2 Decreases Oxidative Stress and Improves Cardiac Remodeling in Rats with Diabetes Mellitus
(Federation Amer Soc Exp Biol, 2016-04-01)
Matrix Metalloproteinase Inhibition Improves Cardiac Dysfunction and Remodeling in 2-Kidney, 1-Clip Hypertension
(CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2010)
Background: Enhanced cardiac matrix metalloproteinase activity (MMPs) has been associated with ventricular remodeling and cardiac dysfunction. It is unknown whether MMPs contribute to systolic/diastolic dysfunction and ...