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Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice
(Frontiers Media Sa, 2017-10-04)
Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA) within several pain-related brain structures. For ...
Prenatal exposure to the CB1 and CB2 cannabinoid receptor agonist WIN 55,212-2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex
(Wiley, 2014-05)
The endocannabinoid system, composed of cannabinoid receptors, endocannabinoids, and synthesis and degradation enzymes, is present since early stages of brain development. During this period, the endocannabinoid system is ...
1-(2,4-diclorofenil)-1H-pirazóis: síntese, análise estrutural e interação com os receptores canabinóides CB1
(Universidade Federal de Santa MariaBRQuímicaUFSMPrograma de Pós-Graduação em Química, 2010-06-25)
A method to obtain fourteen enones [EtO2CC(O)C(R2)=C(R1)OR, where R = H, Me; R1 = Pr, Ph, 4-MeOC6H4, 4-MeC6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-NO2C6H4, Fur- 2-yl; R2 = H; R1,R2 = -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-, ...
Neurobiologia da Cannabis: do sistema endocanabinoide aos transtornos por uso de Cannabis
(Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, 2011-01-01)
OBJECTIVES: Given the challenges arising from the poor effectiveness of therapies for Cannabis-related disorders, the most commonly used illicit drug in the world, this paper aims to review the present knowledge about the ...
Papel da Anandamida na modulação supraespinal da nocicepção e da antinocicepção induzida pelo estresse de derrota social
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2017-09-22)
Anandamide (AEA), initially considered an endocannabinoid, has recently been described as a vanilloid agonist capable of modulating acute pain in brain regions such as the periaqueductal gray (PAG). In this context, AEA ...
Modelling the anti-methicillin-resistant staphylococcus aureus (MRSA) activity of cannabinoids: a QSAR and Docking study
(Corporación Universidad de la Costa, 2020)
The Endocannabinoid System Is Present in Rod Outer Segments from Retina and Is Modulated by Light
(Springer, 2019-04-24)
The aim of the present research was to evaluate if the endocannabinoid system (enzymes and receptors) could bemodulated by light in rod outer segment (ROS) from bovine retina. First, we analyzed endocannabinoid ...
Modelo de interacción molecular de metabolitos presentes en la especie Cannabis satival con la enzima ciclooxigebasa-1 (COX1) y la enzima ciclooxigensa-2 (COX2) de homo sapines
(Bogotá : Universidad de Ciencias Aplicadas y Ambientales, 2019Facultad de CienciasQuímica Farmacéutica, 2019)
En el represente estudio se determinó la interacción molecular de los metabolitos conocidos en la especie Cannabis sativa L. con las dos isoformas de la enzima ciclooxigenasa (COX1 y COX2) de Homo sapiens, a partir del uso ...
Interaction between stress and addiction: Contributions from Latin-American neuroscience
Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit ...
Fibronectin modulates the endocannabinoid system through the cAMP/PKA pathway during human sperm capacitation
(Wiley-liss, Div John Wiley & Sons Inc, 2019-02)
Fibronectin (Fn) enhances human sperm capacitation via the cAMP/PKA pathway, and the endocannabinoid system participates in this process. Moreover, Fn has been linked to endocannabinoid system components in different ...