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The evolutionary history of calreticulin and calnexin genes in green plants
(SpringerDordrechtHolanda, 2011)
Decreased stability of erythroblastic islands in integrin β3-deficient mice
(Wiley, 2013)
Erythroblasts proliferate and differentiate in hematopoietic organs within erythroblastic islands (EI) composed of erythropoietic progenitor cells attached to a central macrophage. This cellular interaction crucially ...
Calreticulin and Calnexin as Chaperones in Glycoprotein Folding
(CRC Press - Taylor & Francis Group, 2009)
Protein folding efficiency is enhanced in vivo by an array of chaperones and folding-assisting enzymes that cover the entire protein folding pathway, from the exit of the polypeptide from the ribosome, its translocation ...
Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy
(Public Library Science, 2015)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-beta (A beta) peptide. We have previously shown that the compound tetrahydrohyperforin (IDN5706) prevents accumulation ...
Getting in and out from calnexin/calreticulin cycles
(American Society for Biochemistry and Molecular Biology, 2008-02)
The N-glycan-dependent quality control mechanism of glycoprotein folding was proposed initially by Helenius and coworkers several years ago; with a few minor modifications, it is still valid today (Fig. 1) (1–3).2 Glycan ...
AtUTr1, a UDP-glucose/UDP-galactose transporter from Arabidopsis thaliana, is located in the endoplasmic reticulum and up-regulated by the unfolded protein response
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2006-04-07)
The folding of glycoproteins in the endoplasmic reticulum (ER) depends on a quality control mechanism mediated by the calnexin/calreticulin cycle. During this process, continuous glucose trimming and UDP-glucose-dependent ...
UDP-Glucose: Glycoprotein Glucosyltransferase 1,2 (UGGT1,2)
(Springer, 2014)
Almost one-third of proteins synthesized by eukaryotic cells belong to the secretory pathway, entering the endoplasmic reticulum (ER) either co- or posttranslationally. In the ER, proteins acquire their native tertiary ...
Clonagem, caracterização e expressão heteróloga de uma calnexina homóloga do fungo patogênico Paracoccidioides brasiliensis
(Universidade Federal de São Paulo (UNIFESP), 2006-01-01)
We report the cloning of a Paracoccidioides brasiliensis cDNA, here named PbCnx, encoding the homologue of the endoplasmic reticulum calnexin. This chaperone specifically recognizes monoglucosylated glycoproteins in the ...