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Junctional ER organization affects mechanotransduction at cadherin-mediated adhesions
(Frontiers Media, 2021)
Cadherin-mediated adhesions (also known as adherens junctions) are adhesive complexes that connect neighboring cells in a tissue. While the role of the actin cytoskeleton in withstanding tension at these sites of contact ...
Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions
(Frontiers Media S.A., 2021)
© Copyright © 2021 Joy-Immediato, Ramirez, Cerda, Toyama, Ravasio, Kanchanawong and Bertocchi.Cadherin-mediated adhesions (also known as adherens junctions) are adhesive complexes that connect neighboring cells in a tissue. ...
Mechanoautophagy: Synergies Between Autophagy and Cell Mechanotransduction at Adhesive Complexes
(FRONTIERS MEDIA SA, 2022)
Cells are exposed and respond to various mechanical forces and physical cues stemming from their environment. This interaction has been seen to differentially regulate various cellular processes for maintenance of homeostasis, ...
E-Cadherin Downregulation is Mediated by Promoter Methylation in Canine Prostate Cancer
(2019-11-29)
E-cadherin is a transmembrane glycoprotein responsible for cell-to-cell adhesion, and its loss has been associated with metastasis development. Although E-cadherin downregulation was previously reported in canine prostate ...
Metformin inhibition of colorectal cancer cell migration is associated with rebuilt adherens junctions and FAK downregulation
(Wiley, 2020-04-02)
E‐cadherin, a central component of the adherens junction (AJ), is a single‐pass trans- membrane protein that mediates cell?cell adhesion. The loss of E‐cadherin surface ex- pression, and therefore cell?cell adhesion, leads ...
Identification of a novel human E-Cadherin splice variant andassessment of its effects upon EMT-related events
(Wiley, 2016-12)
Epithelial Cadherin (E-cadherin) is involved in calcium-dependent cell-cell adhesion and signal transduction. The E-cadherin decrease/loss is a hallmark of Epithelial to Mesenchymal Transition (EMT), a key event in tumor ...
Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer's disease
(Taylor and Francis, 2016)
Prions and Amyloid beta (Aβ) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrPC) acts as a ...
SPARC induces E-cadherin repression and enhances cell migration through integrin v beta 3 and the transcription factor ZEB1 in prostate cancer cells
(MDPI, 2022)
Secreted protein acidic and rich in cysteine (SPARC), or osteonectin, is a matricellular protein that modulates interactions between cells and their microenvironment. SPARC is expressed during extracellular matrix remodeling ...
Loss of retinal cadherin facilitates mammary tumor progression and metastasis
(American Association for Cancer Research, 2009-06)
The mammary epithelium is thought to be stabilized by cellcell adhesion mediated mainly by E-cadherin (E-cad). Here, we show that another cadherin, retinal cadherin (R-cad), is critical for maintenance of the epithelial ...