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Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
(Portland Press, 2004-06-15)
The kininogenase activities of mouse (mK1), rat (rK1) and human (hK1) tissue kallikrems were assayed with the bradykinin-containing synthetic peptides NH2-MTEMARRPPGFSPFRSVTVQ-NH2 (where Abz stands for o-aminobenzoyl) and ...
Kallikrein-kinin system in hepatic experimental models
(Elsevier B.V., 2005-08-01)
The purpose of this brief review is to describe some characteristics of the kallikrein-kinin system (KKS) in the liver. the liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in ...
Human plasma kallikrein. Preliminary studies on hydrolysis of proteins and peptides
(Birkhauser Verlag Ag, 1978-01-01)
Acid-activated human plasma kallikrein (HuPK) was purified from human Cohn fraction IV by affinity chromatography, using as ligand soybean trypsin inhibitor and aminobenzamidine. The purified enzyme does not inactivate ...
Neprilysin carboxydipeptidase specificity studies and improvement in its detection with fluorescence energy transfer peptides
(Walter de Gruyter & Co, 2007-04-01)
We examined the substrate specificity of the carboxydipeptidase activity of neprilysin (NEP) using fluorescence resonance energy transfer (FRET) peptides containing ortho-aminobenzoyl (Abz) and 2,4-dinitrophenyl (Dnp) as ...
Effect of invertebrate serine proteinase inhibitors on carrageenan-induced pleural exudation and bradykinin release
(Elsevier B.V., 2004-10-01)
The carrageenan model of pleurisy is described as temporal plasma exudation (1-5 h) with extensive neutrophil infiltration and release of proteinases into the pleural cavity. the aim of this work was to study the effects ...