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Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B-2-type receptors
(Blackwell Science Asia, 2001-01-01)
Background: We have shown that the portal hypertensive response to bradykinin in normal rats is mediated by B-2 receptors.Methods: By using isolated and exsanguinated rat liver perfusion, we studied the portal hypertensive ...
Kinin-B2 Receptor Mediated Neuroprotection after NMDA Excitotoxicity Is Reversed in the Presence of Kinin-B1 Receptor Agonists
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Background: Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke. Although the actions of bradykinin are in general ...
Is the expression of kinin B-1 receptor related to intrahepatic vascular response?
(Elsevier B.V., 2006-12-01)
Bradykinin elicits an intrahepatic vascular response (IHVR) mediated by the constitutive B-2 receptor (B2R). the biological effects of kinins may also be mediated by the inducible B-1 receptor (B1R). Aim To verify if the ...
IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B 1 and B2 receptors through a STAT6-dependent mechanism
(2013-05-06)
Background and Purpose Bone resorption induced by interleukin-1β (IL-1β) and tumour necrosis factor (TNF-α) is synergistically potentiated by kinins, partially due to enhanced kinin receptor expression. Inflammation-induced ...
IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B 1 and B2 receptors through a STAT6-dependent mechanism
(2013-05-06)
Background and Purpose Bone resorption induced by interleukin-1β (IL-1β) and tumour necrosis factor (TNF-α) is synergistically potentiated by kinins, partially due to enhanced kinin receptor expression. Inflammation-induced ...
Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta
(Associação Brasileira de Divulgação Científica, 2007-05-01)
Previous studies have shown that the vascular reactivity of the mouse aorta differs substantially from that of the rat aorta in response to several agonists such as angiotensin II, endothelin-1 and isoproterenol. However, ...
Differential induction of functional B1-bradykinin receptors along the rat nephron in endotoxin induced inflammation
(Blackwell Science Inc, 1998-12-01)
Background, Under physiological conditions, the effects of kinins in the kidney are mainly mediated by the bradykinin B2-receptor, whereas the kinin B1-receptor is strongly induced under inflammatory conditions in a variety ...
Pharmacological characterization of RMP-7, a novel bradykinin agonist in smooth muscle
(Elsevier B.V., 1999-12-01)
RMP-7 is a bradykinin (BK) agonist designed to be resistant to kininases such as angiotensin-converting enzyme (ACE). Pharmacological assays were performed with RMP-7 in isolated guinea-pig ileum and rat mesenteric artery. ...