Buscar
Mostrando ítems 1-10 de 3040
A thermodynamic analysis of the binding specificity between four human pdz domains and eight host, viral and designed ligands
(MDPI AG, 2021-08)
PDZ domains are binding modules mostly involved in cell signaling and cell–cell junctions. These domains are able to recognize a wide variety of natural targets and, among the PDZ partners, viruses have been discovered to ...
Family 1 carbohydrate binding-modules enhance saccharification rates
(SpringerOpenHeidelberg, 2014-04)
Cellulose degrading enzymes usually have a two-domain structure consisting of a catalytic domain and a non-catalytic carbohydrate-binding module. Although it is well known the importance of those modules in cell wall ...
Functional demonstrations of starch binding domains present in Ostreococcus tauri starch synthases isoforms
(BioMed Central, 2015-10)
Abstract Background: Starch‑binding domains are key modules present in several enzymes involved in polysaccharide metabolism. These non‑catalytic modules have already been described as essential for starch‑binding and the ...
Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)
(Walter De Gruyter & CoBerlinAlemanha, 2003)
ATP-binding cassette exporters: Structure and mechanism with a focus on P-glycoprotein and MRP1
(Bentham Science Publishers, 2019-09)
Background: Proteins that belong to the ATP-binding cassette superfamily include transporters that mediate the efflux of substrates from cells. Among these exporters, P-glycoprotein and MRP1 are involved in cancer multidrug ...
Leaving no stone unturned: Allosteric targeting of SARS-CoV-2 Spike protein at putative druggable sites disrupts human angiotensin-converting enzyme interactions at the receptor binding domain.
The systematic entry of SARS-CoV-2 into host cells, as mediated by its Spike (S) protein, is
highly essential for pathogenicity in humans. Hence, targeting the viral entry mechanisms
remains a major strategy for COVID-19 ...
Crystallization and X-Ray Data Analysis of the Extended Dna-Binding Domain of the E2 Bovine Papillomavirus Type 1 Protein
(Bentham Science Publishers, 2001-08)
Hanging-drop vapour-diffusion method was used for the crystallization of the extended DNA-binding domain (residues 309-410) of the E2 protein from Bovine Papillomavirus Type 1. X-ray data collection at 2.0 A resolution was ...
Uncoupling the Folding and Binding of an Intrinsically Disordered Protein
(Academic Press Ltd - Elsevier Science Ltd, 2018-08)
The relationship between helical stability and binding affinity was examined for the intrinsically disordered transactivation domain of the myeloblastosis oncoprotein, c-Myb, and its ordered binding partner, KIX. A series ...