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Niemann-Pick C2 Protein Expression Regulates Lithogenic Diet-Induced Gallstone Formation and Dietary Cholesterol Metabolism in Mice
(SPRINGER HEIDELBERG, 2012)
Niemann-Pick C2 protein (NPC2) is a lysosomal soluble protein that is highly expressed in the liver; it binds to cholesterol and is involved in intracellular cholesterol trafficking, allowing the exit of lysosomal cholesterol ...
Biliary secretion and hepatic oxidative stress in animals fed with linoleic acid conjugates (CLA)
(Sociedad Argentina de Nutrición, 2008-12)
The purpose of this work was to investigate the effects of CLA at two levels (7 and 20%) of dietary fat on biliary secretion and oxidative stress in liver of rats. Animals were divided in four groups and fed with diets, ...
ENHANCED BILIARY-EXCRETION OF CANALICULAR MEMBRANE ENZYMES IN ESTROGEN-INDUCED AND OBSTRUCTIVE CHOLESTASIS, AND EFFECTS OF DIFFERENT BILE-ACIDS IN THE ISOLATED-PERFUSED RAT-LIVER
(MUNKSGAARD INT PUBL LTD, 1995)
Backgrounds/Aims: Canalicular membrane enzymes are normally released into bile by partially known processes. This study was undertaken to investigate whether hepatocellular cholestasis induced in rats by ethynylestradiol ...
POSTCHOLESTATIC ALKALINE-PHOSPHATASE ACTIVITY AFTER RELIEF OF BILE-DUCT OBSTRUCTION IN THE RAT
(W B SAUNDERS CO, 1993)
The effects of obstructive cholestasis on the activity of alkaline phosphatase have been extensively studied in serum and liver tissue. However, very little is known about the activity of this enzyme in the postcholestatic ...
Relevance of Niemann-Pick type C1 protein expression in controlling plasma cholesterol and biliary lipid secretion in mice
(WILEY, 2002)
Receptor-mediated endocytosis is one of the major mechanisms for uptake of lipoprotein cholesterol in the liver. Because Niemann-Pick C1 (NPC1) protein is a key component in the intracellular distribution of cholesterol ...
The molecular and metabolic basis of biliary cholesterol secretion and gallstone disease
(FRONTIERS IN BIOSCIENCE PUBLICATIONS, 2003)