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Adaptive regulation of hepatic bile salt transport: Role of bile salt hydrophobicity and microtubule-dependent vesicular pathway
(MUNKSGAARD INT PUBL LTD, 1997)
Background/Aims: The hepatic transport of bile salts can be regulated by changes in bile salt pool size and/ or in the flux of bile salts through the liver, Prolonged bile salt pool depletion is associated with down-regulation ...
Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits
(LIPID RESEARCH INC, 2000)
We investigated the effect of heal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits. Bile acid pool sizes, fecal bile acid outputs (synthesis rates), ...
Cholestasis: The Close Relationship between Bile Acids and Coenzyme Q10
(Intech Open, 2019)
Cholestasis is defined as the impairment in formation or excretion of bile from the liver to the intestine. It may result from defects in intrahepatic production of bile, impairment of hepatic transmembrane transporters, ...
ADAPTIVE REGULATION OF HEPATIC BILE-SALT TRANSPORT - EFFECTS OF ALLOXAN DIABETES IN THE RAT
(W B SAUNDERS CO, 1991)
The hepatic transport of bile salts appears to be adaptively regulated by changes in the bile salt pool size and in the flux of bile salt through the liver. The maximum secretory rate of taurocholate increases or decreases ...
Adenovirus-mediated human aquaporin-1 expression in hepatocytes improves lipopolysaccharide-induced cholestasis
(John Wiley & Sons Inc, 2017-12)
Lipopolysaccharides (LPS) are known to cause cholestasis in sepsis. There is evidence that a defective expression of canalicular aquaporin water channels contributes to bile secretory failure in LPS-induced cholestasis. ...
ENHANCED BILIARY-EXCRETION OF CANALICULAR MEMBRANE ENZYMES IN ETHYNYLESTRADIOL-INDUCED CHOLESTASIS - EFFECTS OF URSODEOXYCHOLIC ACID ADMINISTRATION
(PERGAMON-ELSEVIER SCIENCE LTD, 1995)
Cholestasis is associated with a marked increase in the release of canalicular membrane enzymes into bile. This phenomenon has been related to an increased lability of these canalicular membrane integral proteins to the ...
Aquaporin gene therapy for cholestasis
(John Wiley & Sons Inc, 2017-01)
This is regarding the editorial “Aquaporin gene therapy for disorders of cholestasis?” by Tradtrantip and Verkman.(1) We thank the authors for their comments in our recent studies.(2,3) Nevertheless, we believe that an ...
Bile Acids and Nonalcoholic Fatty Liver Disease: Molecular Insights and Therapeutic Perspectives
(2017)
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing prevalence of this disease and of its ...
Down-regulation of the Na+/taurocholate cotransporting polypeptide during pregnancy in the rat
(ELSEVIER SCIENCE BV, 2003)
Background: Experimental studies have shown decreased bile acid (BA) uptake and reduced excretion of cholephilic compounds in pregnant rodents.