Buscar
Mostrando ítems 1-10 de 83
Synthesis of multicyclic β-Lactam derivatives via solid-phase- generated ketenes
(American Chemical Society, 2010-09)
An efficient approach for the solid-phase synthesis of multicyclic â-lactam derivatives is described. The key step is the cycloaddition reaction between an immobilized ketene and different cyclic imines to afford the ...
Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
(Molecular Diversity Preservation International, 2018-05)
The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis ...
Effect of micelles, microemulsions and other supramolecular aggregates on the hydrolysis of β-lactam antibiotics
(1999-12-01)
A critical revision of the literature was made regarding the stability of β-lactam antibiotics in the presence of surfactants. The factors involved in the drug decomposition were analyzed in the development of the discussion. ...
Effect of micelles, microemulsions and other supramolecular aggregates on the hydrolysis of β-lactam antibiotics
(1999-12-01)
A critical revision of the literature was made regarding the stability of β-lactam antibiotics in the presence of surfactants. The factors involved in the drug decomposition were analyzed in the development of the discussion. ...
1,3-Dipolar cycloaddition of nitrile imines with alpha,beta-unsaturated lactones, thiolactones and lactams: synthesis of ring-fused pyrazoles
(PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND, 2012)
Recent approaches toward the generation of molecular diversity based on b-lactam structures
(Springer, 2017)
One of the most significant strategies in the search of biologically promising structures is the generation of scaffold diversity. Varying molecular scaffolds yielded useful small molecule tools for chemical genetic studies ...
Uso de beta-lactámicos como alternativa del tratamiento empírico actual de sepsis neonatal tardía: revisión temática
(Universidad de Chile. Facultad de Medicina, 2019)
Objetivo: Analizar el uso de beta-lactámicos en sepsis neonatal tardía, en comparación con el tratamiento empírico actual con vancomicina, mediante la revisión de artículos científicos. Metodología: Revisión temática en ...