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Alpha-secretase-derived fragment of cellular prion, n1, protects against monomeric and oligomeric amyloid beta (a beta)-associated cell death
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012)
Adaptor protein 2-mediated endocytosis of the beta-secretase bace1 is dispensable for amyloid precursor protein processing
(AMERICAN SOCIETY FOR CELL BIOLOGY, 2012)
Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage
(Elsevier, 2013-11)
Amyloid precursor protein (APP) shedding yields the Alzheimer´s disease (AD)-related peptide amyloid B (AB) through beta- and gamma-secretase cleavage. Alternatively, alpha-secretase cleavage generates a soluble and ...
Avaliação por bioquímica quântica de interações entre o receptor beta secretase 1 (BACE1) e Ligantes
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS, 2021-12-02)
Alzheimer's disease (AD) is a progressive multifactorial
neurodegenerative disorder and the main cause of dementia in late adulthood.
The amyloid cascade hypothesis suggests a deposition of beta amyloid (Aβ) in
the brain, ...
PSEN1 and PSEN2 Gene Expression in Alzheimer's Disease Brain: A New Approach
(Ios Press, 2014-01-01)
Presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of ...