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Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors
(MACMILLAN JOURNALS, 2005)
N-SUBSTITUTION AND á1-ADRENERGIC RECEPTOR AFFINITY OF LAUDANOSINE ANALOGUES
(Sociedad Chilena de Química, 2006)
Synthesis and Dopamine Receptor Selectivity of the Benzyltetrahydroisoquinoline, (R)-(+)-nor-Roefractine
(American Chemical Society and American Society of Pharmacognosy, 1998-01-15)
(R)-(+)-nor-Roefractine (1) was synthesized
by the Bischler-Napieralski route, using asymmetric
reduction of the 1,2-didehydro precursor imine with
sodium (S)-N-CBZ-prolinyloxyborohydride. Compound
1 was able to displace ...
Antioxidant and antimicrobial activities of aporphinoids and other alkaloids from the bark of Annona salzmannii A. DC. (Annonaceae)
(Taylor & Francis LtdAbingdonInglaterra, 2013)
Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors
(Nature Publishing Group, 2005-06-27)
1 Effects of derivatives of coclaurine (C), which mimic the ‘eastern’ or the nonquaternary halves of
the alkaloids tetrandrine or d-tubocurarine, respectively, both of which are inhibitors of nicotinic
acetylcholine ...
Structure–activity relationship of dopaminergic halogenated 1-benzyl-tetrahydroisoquinoline derivatives
(Elsevier France-editions Scientifiques Medicales Elsevier, 2009-11)
Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to explore the influence of each series on the affinity for dopamine receptors. All the compounds displayed a high affinity for ...
Molecular recognition and binding mechanism of N-alkyl- benzyltetrahydroisoquinolines to the D1 dopamine receptor. A computational approach
(Elsevier Science, 2003-12)
In order to better understand, at sub-molecular level, the minimal structural requirements for the recognition process in the inhibitory activity, a series of N-alkyl-benzyltethrahydroisoquinolines (BTHIQs) were examined ...
N-SUBSTITUTION AND α1-ADRENERGIC RECEPTOR AFFINITY OF LAUDANOSINE ANALOGUES
(Sociedad Chilena de Química, 2006-09)
Benzyltetrahydroisoquinoline (BTHIQ) molecules are able to adopt widely differing conformations that depend on the presence or absence of N-substituents.
To assess the possible role of BTHIQ conformation on the affinity ...