Proteins containing a bHLH domain (referred to as bHLH proteins), are involved in a wide variety of regulatory processes, such as neurogenesis, myogenesis, animal heart development, phosphate uptake control, yeast glycolysis, ...

Hypoxia-inducible factor alpha (HIF-alpha) proteins are regulated by oxygen levels through several different mechanisms that include protein stability, transcriptional coactivator recruitment, and subcellular localization. ...

Jasmonates (JAs) are phytohormones regulating stress responses and developmental processes. The role of JAs is well known in Arabidopsis, in which they control flavonoid compounds accumulation like anthocyanins, through ...

The plant hormone jasmonate (JA) activates gene expression by promoting ubiquitin-dependent degradation of JAZ transcriptional repressor proteins. A key feature of all JAZ proteins is the highly conserved Jas motif, which ...

The bHLH family is composed by canonical and non-canonical transcription factors (TFs) that differ in the presence or absence of their DNA-binding domain, respectively. Since both types of bHLH proteins are able to dimerize, ...

In mammalian systems, the heterodimeric basic helix-loop-helix (bHLH)-PAS transcription hypoxia-inducible factor (HIF) has emerged as the key regulator of responses to hypoxia. Here we define a homologous system in Drosophila ...

Los jasmonatos (JAs) son fitohormonas que regulan respuestas frente a estrés y procesos del desarrollo. Su rol está bien elucidado en la planta modelo Arabidopsis, donde se ha determinado su participación en la acumulación ...

The large number of complete mitochondrial DNA (mtDNA) sequences available for metazoan species makes it a good system for studying genome diversity, although little is known about the mechanisms that promote and/or are ...