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Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis
(University of Chicago Press, 2016)
Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase i and II
(American Chemical Society, 2019-08-13)
Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of (3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogues with up to a 1000-fold increase ...
Arginase-endothelial nitric oxide synthase imbalance contributes to endothelial dysfunction during chronic intermittent hypoxia
(Lippincott Williams and Wilkins, 2015)
Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury
(American Chemical Society, 2013-03)
Recent efforts to identify treatments for myocardial ischemia reperfusion injury have resulted in the discovery of a novel series of highly potent α,α-disubstituted amino acid-based arginase inhibitors. The lead candidate, ...
Epigenetic mechanisms implicated in the programming of endothelial dysfunctión in foetuses with intrauterine growth restrictión
(2014)
The association between reduced foetal growth and adult health has risen as a feasible explanation for non-Mendelian diseases, such as hypertension and type-2 diabetes. Epigenetic mechanisms (i.e. DNA methylation, histone ...