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Different profiles of circulating arginase 2 in subtypes of preeclampsia pregnant women
(Elsevier B.V., 2021-06-01)
Background and aims: Preeclampsia (PE) is a gestational hypertensive disease responsible for high maternal and fetal morbidity and mortality. The increase in blood pressure is associated with a decrease in the bioavailability ...
Evidence for cooperative effects in human liver arginase
(1982)
The reaction kinetics of human liver arginase (l-arginine amidinohydrolase, EC 3.5.3.1) in terms of arginine concentration is strikingly altered by varying the pH. Lowering the pH from the optimum (9.5) toward a more ...
The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012)
Polyamine biosynthesis enzymes are promising drug targets for the treatment of leishmaniasis, Chagas' disease and African sleeping sickness. Arginase, which is a metallohydrolase, is the first enzyme involved in polyamine ...
Hypoxia-reduced nitric oxide synthase activity is partially explained by higher arginase-2 activity and cellular redistribution in human umbilical vein endothelium
(W B SAUNDERS CO LTD, 2011)
Hypoxia relates with altered placental vasodilation, and in isolated endothelial cells, it reduces activity of the endothelial nitric oxide synthase (eNOS) and L-arginine transport. It has been reported that arginase-2 ...
A relação arginase-óxido nítrico na infecção experimental por Leishmania braziliensis
(Centro de Pesquisas Gonçalo Moniz, 2013)
Interferon-γ priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG motifs in murine macrophages
(Wiley Blackwell Publishing, Inc, 2009-09)
Recognition of microbial products by macrophages (Mph) stimulates an inflammatory response and plays a critical role in directing the host immune response against infection. In the present work, we showed for the first ...
Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis
(University of Chicago Press, 2016)
Inhibition of Leishmania amazonensis arginase by fucogalactan isolated from Agrocybe aegerita mushroom
(Elsevier B.V., 2018-12-01)
The inhibition of arginase from Leishmania spp. is considered a promising approach to the leishmaniasis treatment. In this study, the potential of a fucogalactan isolated from the medicinal mushroom Agrocybe aegerita was ...
Arginase 1 is a marker of protection against illness in contacts of leprosy patients
(Nature Portfolio, 2022)