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Monoaminergic, Ion Channel and Enzyme Inhibitory Activities of Natural Aporphines, their Analogues and Derivatives
(EDITORIAL BOARD, 2007-12-01)
The aporphine alkaloids constitute the second-largest group of isoquinoline alkaloids. Nevertheless, only a relatively small
number of natural aporphines and their derivatives have been studied from a pharmacological ...
Effects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice
(Elsevier, 2003)
(S)-(+)-boldine, an aporphine alkaloid displaying antioxidative and dopaminergic properties, and six of its derivatives (glaucine, 3-bromoboldine, 3-iodoboldine, 8-aminoboldine, 8-nitrosoboldine and 2,9-O,O′-dipivaloylboldine) ...
E ffects of some antioxidative aporphine derivatives on striatal dopaminergic transmission and on MPTP-induced striatal dopamine depletion in B6CBA mice
(Elsevier Science B.V., 2002-11-20)
(S)-(1)-boldine, an aporphine alkaloid displaying antioxidative and dopaminergic properties, and six of its derivatives (glaucine,
3-bromoboldine, 3-iodoboldine, 8-aminoboldine, 8-nitrosoboldine and 2,9-O,O9 -dipivaloylboldine) ...
Oxoisoaporphines and aporphines: Versatile molecules with anticancer Efects
(MDPI, 2020)
Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity. ...
Monoaminergic, ion channel and enzyme inhibitory activities of natural aporphines, their analogues and derivatives
(NATURAL PRODUCTS INC, 2008)
Structure-affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: Halogenation and D1 receptor selectivity
(Elsevier Ltd, 2005)
Halogenation of the aporphine alkaloid boldine at the 3-position leads to increased affinity for rat brain D1-like dopaminergic receptors with some selectivity over D2-like receptors. A series of 3-halogenated and ...
8-NH2-boldine, an antagonist of α1A and α1B adrenoceptors without affinity for the α1D subtype: Structural requirements for aporphines at α1- adrenoceptor subtypes
(2005)
Structure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for cloned human α1A, α1B and α1D adrenoceptors (AR) using membranes prepared from rat-1 fibroblasts stably expressing ...
8-NH2-Boldine, an Antagonist of alA and a18 Adrenoceptors without Affinity for the alD Subtype: Structural Requirements for Aporphines at al-Adrenoceptor Subtypes
(Georg Thieme, 2005-04-13)
5tructure-activity analysis of 21 aporphine derivatives was performed
by examining their affinities for c10ned human alA. alB
and alD adrenoceptors (AR) using membranes prepared from
rat -1 fibroblasts stably expressing ...
A possible structural determinant of selectivity of boldine and derivatives for the α1A-adrenoceptor subtype
(John Wiley and Sons Inc., 1996)
1 The selectivity of action of boldine and the related aporphine alkaloids, predicentrine (9-O-methylboldine) and glaucine (2,9-O-dimethylboldine) on α1-adrenoceptor subtypes was studied by examining [3H]-prazosin competition ...